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												 Viewpoint 
												Cybersecurity Lessons From the Change Healthcare Attack
												Hannah T. Neprash, PhD; Christian Dameff, MD, MS; Jeffrey Tully, MD 
												Original Investigation 
												Nurse-Supported Self-Directed Cognitive Behavioral Therapy for Insomnia: A Randomized Clinical Trial
												Christi S. Ulmer, PhD, DBSM; Corrine I. Voils, PhD; Amy S. Jeffreys, MStat; et al. 
												Lactated Ringer vs Normal Saline Solution During Sickle Cell Vaso-Occlusive Episodes
												Augusta K. Alwang, MD; Anica C. Law, MD, MS; Elizabeth S. Klings, MD; et al. 
												Invited Commentary 
												Charting the Waters of Sickle Cell Disease With Target Trial Emulation
												A. Parker Ruhl, MD, MHS; Matthew M. Hsieh, MD; Elizabeth A. Stuart, PhD 
												Comment & Response 
												Cytisinicline For E-Cigarette Cessation
												Rongzhong Huang, MD, PhD; Tianyang Hu, MD, PhD 
												Cytisinicline For E-Cigarette Cessation
												Adam Edward Lang, PharmD 
												Cytisinicline For E-Cigarette Cessation—Reply
												Nancy A. Rigotti, MD; Neal L. Benowitz, MD; Cindy Jacobs, PhD, MD 
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