New Issue: Sacubitril/Valsartan and Heart Failure, Prior SARS-CoV-2 Infection and Breakthrough Infection Following mRNA Vaccination, COVID-19 and In-Hospital Mortality With Myocardial Infarction, and more

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New Issue

NOVEMBER 16, 2021; VOLUME 326, NUMBER 19
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IN THIS ISSUE OF JAMA

Audio Highlights

Audio Editors' Summary: Sacubitril/Valsartan and Heart Failure, Prior SARS-CoV-2 Infection and Breakthrough Infection Following mRNA Vaccination, COVID-19 and In-Hospital Mortality With Myocardial Infarction, and more

ORIGINAL INVESTIGATION

Effect of Sacubitril/Valsartan vs Standard Medical Therapies on Plasma NT-proBNP Concentration and Submaximal Exercise Capacity in Patients With Heart Failure and Preserved Ejection Fraction: The PARALLAX Randomized Clinical Trial

Burkert Pieske, MD; Rolf Wachter, MD; Sanjiv J. Shah, MD; et al.

Earn CME credit

Editorial: Quality of Life and Exercise Ability in Heart Failure With Preserved Ejection Fraction: No Time for Therapeutic Complacency; Margaret M. Redfield, MD; Barry A. Borlaug, MD

Association of Prior SARS-CoV-2 Infection With Risk of Breakthrough Infection Following mRNA Vaccination in Qatar

Laith J. Abu-Raddad, PhD; Hiam Chemaitelly, MSc; Houssein H. Ayoub, PhD; et al.

Earn CME credit

Association Between COVID-19 Diagnosis and In-Hospital Mortality in Patients Hospitalized With ST-Segment Elevation Myocardial Infarction

Marwan Saad, MD, PhD; Kevin F. Kennedy, MS; Hafiz Imran, MD; et al.

Editorial: Myocardial Infarction During the COVID-19 Pandemic; Alexander C. Fanaroff, MD, MHS; Santiago Garcia, MD; Jay Giri, MD, MPH

RESEARCH LETTER

Prehospital Treatment of Status Epilepticus in the United States

Elan L. Guterman, MD, MAS; James F. Burke, MD, MS; Karl A. Sporer, MD

Changes in COVID-19 Vaccine Intent From April/May to June/July 2021

Peter G. Szilagyi, MD, MPH; Kyla Thomas, PhD; Megha D. Shah, MD, MPH, MS; et al.

US PREVENTIVE SERVICES TASK FORCE

USPSTF Approach to Addressing Sex and Gender When Making Recommendations for Clinical Preventive Services

Aaron B. Caughey, MD, MPH, PhD; Alex H. Krist, MD, MPH; Tracy A. Wolff, MD, MPH; et al.

VIEWPOINT

Diagnostic Excellence

Diagnostic Excellence

Daniel Yang, MD; Harvey V. Fineberg, MD, PhD; Karen Cosby, MD

Audio Author Interview: Achieving Diagnostic Excellence in the 21st Century

Diagnostic Excellence

Diagnosis and the Illness Experience: Ways of Knowing

Amrapali Maitra, MD, PhD; Abraham Verghese, MD

Audio Author Interview: Achieving Diagnostic Excellence in the 21st Century

The Financial Effects and Consequences of COVID-19: A Gathering Storm

John A. Graves, PhD; Khrysta Baig, MSPH; Melinda Buntin, PhD

A PIECE OF MY MIND

What Makes Us Know We’re Alive

Haley Newman, MD

EDITORIAL

Quality of Life and Exercise Ability in Heart Failure With Preserved Ejection Fraction: No Time for Therapeutic Complacency

Margaret M. Redfield, MD; Barry A. Borlaug, MD

Myocardial Infarction During the COVID-19 Pandemic

Alexander C. Fanaroff, MD, MHS; Santiago Garcia, MD; Jay Giri, MD, MPH

JAMA INSIGHTS

Women's Health

Evaluation and Management of Amenorrhea

Sarah Pitts, MD; Amy D. DiVasta, MD, MMSc; Catherine M. Gordon, MD, MSc

JAMA CLINICAL GUIDELINES SYNOPSIS

Managing Adult Acute and Acute-on-Chronic Liver Failure in the ICU

Xuan Han, MD, MS; Andrew M. Davis, MD, MPH; William F. Parker, MD, PhD

JAMA DIAGNOSTIC TEST INTERPRETATION

Electrodiagnostic Testing for Diagnosing Polyneuropathy

Ryan D. Jacobson, MD; Michelle Glantz, DO

Earn CME credit

MEDICAL NEWS & PERSPECTIVES

Monoclonal Antibodies for COVID-19 Preexposure Prophylaxis Can’t Come Fast Enough for Some People

Rita Rubin, MA

NEWS FROM THE FOOD AND DRUG ADMINISTRATION

Surgical Staplers to Undergo More Stringent Review for Safety Reasons

Rebecca Voelker, MSJ

Some Companies Will Stop Making Alcohol-Based Hand Sanitizer

Rebecca Voelker, MSJ

Needle-Free Dermal Filler Injectors Prompt Safety Warning

Rebecca Voelker, MSJ

GLOBAL HEALTH

Global Plan Targets Elimination of Bacterial Meningitis Epidemics

Bridget M. Kuehn, MSJ

WHO, Global Health Workers Demand Urgent Action on Climate Change

Bridget M. Kuehn, MSJ

Lack of Adolescents’ Mental Health Care Is a Global Challenge

Bridget M. Kuehn, MSJ

POETRY AND MEDICINE

Last-Minute Pedicure

Judith Harris

JAMA REVISITED

“Opium Antidotes,” and Their Vendors: J. B. Mattison, M.D.

JAMA PATIENT PAGE

Bell Palsy

Lanning B. Kline, MD; Malcolm M. Kates, MD; Mehdi Tavakoli, MD

AUDIO

Audio Editors' Summary

Sacubitril/Valsartan and Heart Failure, Prior SARS-CoV-2 Infection and Breakthrough Infection Following mRNA Vaccination, COVID-19 and In-Hospital Mortality With Myocardial Infarction, and more

Audio Author Interview

Achieving Diagnostic Excellence in the 21st Century

COMMENT & RESPONSE

Platelet-Rich Plasma Injection vs Sham Injection and Tendon Dysfunction in Patients With Chronic Midportion Achilles Tendinopathy

Vincent Gremeaux, MD, PhD; Eric Noël, MD; Jean-Francois Kaux, MD, PhD

Platelet-Rich Plasma Injection vs Sham Injection and Tendon Dysfunction in Patients With Chronic Midportion Achilles Tendinopathy

Gerard A. Malanga, MD; Ken Mautner, MD; Don Buford, MD

Platelet-Rich Plasma Injection vs Sham Injection and Tendon Dysfunction in Patients With Chronic Midportion Achilles Tendinopathy

Kuan-Kai Tung, MD; James Cheng-Chung Wei, MD, PhD

Platelet-Rich Plasma Injection vs Sham Injection and Tendon Dysfunction in Patients With Chronic Midportion Achilles Tendinopathy—Reply

Rebecca S. Kearney, PhD; Matthew L. Costa, PhD

A Review of the Diagnosis and Treatment of Alcohol-Associated Liver Disease

Lanla Conteh, MD, MPH, MBA; Douglas Levin, MD

A Review of the Diagnosis and Treatment of Alcohol-Associated Liver Disease—Reply

Ashwani K. Singal, MD; Philippe Mathurin, MD

A Hospital and Postdischarge Quality Improvement Intervention and Outcomes and Care for Patients With Heart Failure With Reduced Ejection Fraction

Daniel S. Kim, MD; Nhu Quyen Dau, PharmD; Harry Peled, MD

A Hospital and Postdischarge Quality Improvement Intervention and Outcomes and Care for Patients With Heart Failure With Reduced Ejection Fraction—Reply

Adam D. DeVore, MD, MHS; Bradi Granger, PhD, RN; Adrian F. Hernandez, MD, MHS

JAMA MASTHEAD

JAMA

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