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IN THIS ISSUE OF JAMA
Audio Highlights
Audio Editors' Summary: Sacubitril/Valsartan and Heart Failure, Prior SARS-CoV-2 Infection and Breakthrough Infection Following mRNA Vaccination, COVID-19 and In-Hospital Mortality With Myocardial Infarction, and more
ORIGINAL INVESTIGATION
Effect of Sacubitril/Valsartan vs Standard Medical Therapies on Plasma NT-proBNP Concentration and Submaximal Exercise Capacity in Patients With Heart Failure and Preserved Ejection Fraction: The PARALLAX Randomized Clinical Trial
Burkert Pieske, MD; Rolf Wachter, MD; Sanjiv J. Shah, MD; et al.
Earn CME credit
Editorial: Quality of Life and Exercise Ability in Heart Failure With Preserved Ejection Fraction: No Time for Therapeutic Complacency; Margaret M. Redfield, MD; Barry A. Borlaug, MD
Association of Prior SARS-CoV-2 Infection With Risk of Breakthrough Infection Following mRNA Vaccination in Qatar
Laith J. Abu-Raddad, PhD; Hiam Chemaitelly, MSc; Houssein H. Ayoub, PhD; et al.
Earn CME credit
Association Between COVID-19 Diagnosis and In-Hospital Mortality in Patients Hospitalized With ST-Segment Elevation Myocardial Infarction
Marwan Saad, MD, PhD; Kevin F. Kennedy, MS; Hafiz Imran, MD; et al.
Editorial: Myocardial Infarction During the COVID-19 Pandemic; Alexander C. Fanaroff, MD, MHS; Santiago Garcia, MD; Jay Giri, MD, MPH
RESEARCH LETTER
Prehospital Treatment of Status Epilepticus in the United States
Elan L. Guterman, MD, MAS; James F. Burke, MD, MS; Karl A. Sporer, MD
Changes in COVID-19 Vaccine Intent From April/May to June/July 2021
Peter G. Szilagyi, MD, MPH; Kyla Thomas, PhD; Megha D. Shah, MD, MPH, MS; et al.
US PREVENTIVE SERVICES TASK FORCE
USPSTF Approach to Addressing Sex and Gender When Making Recommendations for Clinical Preventive Services
Aaron B. Caughey, MD, MPH, PhD; Alex H. Krist, MD, MPH; Tracy A. Wolff, MD, MPH; et al.
VIEWPOINT
Diagnostic Excellence
Diagnostic Excellence
Daniel Yang, MD; Harvey V. Fineberg, MD, PhD; Karen Cosby, MD
Audio Author Interview: Achieving Diagnostic Excellence in the 21st Century
Diagnostic Excellence
Diagnosis and the Illness Experience: Ways of Knowing
Amrapali Maitra, MD, PhD; Abraham Verghese, MD
Audio Author Interview: Achieving Diagnostic Excellence in the 21st Century
The Financial Effects and Consequences of COVID-19: A Gathering Storm
John A. Graves, PhD; Khrysta Baig, MSPH; Melinda Buntin, PhD
A PIECE OF MY MIND
What Makes Us Know We’re Alive
Haley Newman, MD
EDITORIAL
Quality of Life and Exercise Ability in Heart Failure With Preserved Ejection Fraction: No Time for Therapeutic Complacency
Margaret M. Redfield, MD; Barry A. Borlaug, MD
Myocardial Infarction During the COVID-19 Pandemic
Alexander C. Fanaroff, MD, MHS; Santiago Garcia, MD; Jay Giri, MD, MPH
JAMA INSIGHTS
Women's Health
Evaluation and Management of Amenorrhea
Sarah Pitts, MD; Amy D. DiVasta, MD, MMSc; Catherine M. Gordon, MD, MSc
JAMA CLINICAL GUIDELINES SYNOPSIS
Managing Adult Acute and Acute-on-Chronic Liver Failure in the ICU
Xuan Han, MD, MS; Andrew M. Davis, MD, MPH; William F. Parker, MD, PhD
JAMA DIAGNOSTIC TEST INTERPRETATION
Electrodiagnostic Testing for Diagnosing Polyneuropathy
Ryan D. Jacobson, MD; Michelle Glantz, DO
Earn CME credit
MEDICAL NEWS & PERSPECTIVES
Monoclonal Antibodies for COVID-19 Preexposure Prophylaxis Can’t Come Fast Enough for Some People
Rita Rubin, MA
NEWS FROM THE FOOD AND DRUG ADMINISTRATION
Surgical Staplers to Undergo More Stringent Review for Safety Reasons
Rebecca Voelker, MSJ
Some Companies Will Stop Making Alcohol-Based Hand Sanitizer
Rebecca Voelker, MSJ
Needle-Free Dermal Filler Injectors Prompt Safety Warning
Rebecca Voelker, MSJ
GLOBAL HEALTH
Global Plan Targets Elimination of Bacterial Meningitis Epidemics
Bridget M. Kuehn, MSJ
WHO, Global Health Workers Demand Urgent Action on Climate Change
Bridget M. Kuehn, MSJ
Lack of Adolescents’ Mental Health Care Is a Global Challenge
Bridget M. Kuehn, MSJ
POETRY AND MEDICINE
Last-Minute Pedicure
Judith Harris
JAMA REVISITED
“Opium Antidotes,” and Their Vendors: J. B. Mattison, M.D.
JAMA PATIENT PAGE
Bell Palsy
Lanning B. Kline, MD; Malcolm M. Kates, MD; Mehdi Tavakoli, MD
AUDIO
Audio Editors' Summary
Sacubitril/Valsartan and Heart Failure, Prior SARS-CoV-2 Infection and Breakthrough Infection Following mRNA Vaccination, COVID-19 and In-Hospital Mortality With Myocardial Infarction, and more
Audio Author Interview
Achieving Diagnostic Excellence in the 21st Century
COMMENT & RESPONSE
Platelet-Rich Plasma Injection vs Sham Injection and Tendon Dysfunction in Patients With Chronic Midportion Achilles Tendinopathy
Vincent Gremeaux, MD, PhD; Eric Noël, MD; Jean-Francois Kaux, MD, PhD
Platelet-Rich Plasma Injection vs Sham Injection and Tendon Dysfunction in Patients With Chronic Midportion Achilles Tendinopathy
Gerard A. Malanga, MD; Ken Mautner, MD; Don Buford, MD
Platelet-Rich Plasma Injection vs Sham Injection and Tendon Dysfunction in Patients With Chronic Midportion Achilles Tendinopathy
Kuan-Kai Tung, MD; James Cheng-Chung Wei, MD, PhD
Platelet-Rich Plasma Injection vs Sham Injection and Tendon Dysfunction in Patients With Chronic Midportion Achilles Tendinopathy—Reply
Rebecca S. Kearney, PhD; Matthew L. Costa, PhD
A Review of the Diagnosis and Treatment of Alcohol-Associated Liver Disease
Lanla Conteh, MD, MPH, MBA; Douglas Levin, MD
A Review of the Diagnosis and Treatment of Alcohol-Associated Liver Disease—Reply
Ashwani K. Singal, MD; Philippe Mathurin, MD
A Hospital and Postdischarge Quality Improvement Intervention and Outcomes and Care for Patients With Heart Failure With Reduced Ejection Fraction
Daniel S. Kim, MD; Nhu Quyen Dau, PharmD; Harry Peled, MD
A Hospital and Postdischarge Quality Improvement Intervention and Outcomes and Care for Patients With Heart Failure With Reduced Ejection Fraction—Reply
Adam D. DeVore, MD, MHS; Bradi Granger, PhD, RN; Adrian F. Hernandez, MD, MHS
JAMA MASTHEAD
JAMA
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