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JAMA+ AI Update: September 12, 2026

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Update

September 12, 2026

Could AI predict and prevent age-related diseases? Could AI help restore the patient-doctor relationship? Or will it exacerbate existing challenges in providing health care?

In this episode of JAMA+ AI Conversations, Eric Topol, MD, Director and Founder of the Scripps Research Translational Institute, speaks with JAMA+ AI Editor in Chief Roy Perlis, MD, MSc, about aging, AI, and predicting the future.

Topol discusses what it will take for AI to move medicine from reactive to predictive, why some well-validated imaging AI remains underused even as the applications of large language models have spread rapidly, and whether AI is actually giving clinicians more time with patients.

Listen now on Spotify | Apple Podcasts | YouTube | JAMA.com.

Editor’s Picks in this week’s JAMA+ AI:

  • A clinical trial found that digital outreach helped patients at high risk for cardiovascular disease refill their statin prescriptions more often than usual communication methods. Secure patient portal messages and text messages were the most effective, suggesting that digital tools can be a practical way to improve medication adherence. (JAMA)
  • Prefer a quick overview? Read the JAMA Research Summary explaining this study of digital patient communication. (JAMA)
  • In a related JAMA Editorial, the author notes that absolute refill rates of statins remained low in the ASCVD trial, suggesting that brief digital outreach alone may not substantially close persistent gaps in treatment adherence. However, the editorial notes that the trial provides a model for rapid and rigorous testing within an existing health system infrastructure, even as the search continues for more effective solutions. (JAMA)

Multimedia

JAMA

From Aging to AI and Beyond: A Conversation With Eric Topol

Roy Perlis, MD, MSc

Original Investigation

JAMA

Digital Outreach to Improve Statin Refills in Patients With Low Statin Adherence: The ADHERE-ASCVD Randomized Clinical Trial

Ankeet S. Bhatt, MD, MBA, ScM; Vincent X. Liu, MD, MS; Baiyang Sun, PhD, MPH; et al

Editorial

JAMA

Small Gains but Persistent Gaps in Statin Adherence

Luke J. Laffin, MD

Research Summary

JAMA

Digital Outreach to Improve Statin Refills in Patients With Low Statin Adherence

AUDIO

From Aging to AI and Beyond: A Conversation With Eric Topol

(23 min 8 sec)


Read and download the JAMA Summit Report on Firearm Violence

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