JAMA+ Trials Update September 3, 2026

TRIAL THEME OF THE MONTH

Alison J. Huang, MD, MAS; Thomas G. Travison, PhD; Derek C. Angus, MD, MPH

What makes a clinical trial a "pragmatic" trial? Since the concept of pragmatic trial research was introduced nearly 60 years ago, this label has been applied and interpreted beyond its original meaning. Today, pragmatic interventional research is characterized by definitional confusion and heterogeneity in how pragmatic design features are operationalized and justified.

Read the Editorial

EDITOR’S CHOICE: CLINICAL TRIAL OF THE YEAR

Amélie Cambriel, MD; Amy Tsai, MD; Benjamin Choisy, MD; et al

Find out why JAMA Surgery Editor Dr Melina Kibbe thinks her trial pick of the year "provides a framework for the next generation of prehabilitation that is data driven, mechanism based, and patient specific."

Read the Editor's Note

GUIDE TO STATISTICS & METHODS FOR TRIALS

JAMA Guide to Statistics & Methods

Harold C. Sox, MD; Roger J. Lewis, MD, PhD

Audio / JAMA Guide to Statistics & Methods

Michelle A. Detry, PhD; Roger J. Lewis, MD, PhD

Research, Reviews, and Commentary

Original Investigation | JAMA Oncology

Joseph M. Unger, PhD; Hong Xiao, PhD; Michael L. LeBlanc, PhD; et al

Research Letter | JAMA Network Open

Sneha Ahuja, BS; Carl Jay E. Jainar, MD; Sara Moufarrij, MD; et al

Editorial | JAMA

Spyridon P. Basourakos, MD; Jonathan E. Shoag, MD; Daniel E. Spratt, MD

Viewpoint | JAMA Oncology

Neil Vasan, MD, PhD

Search & Browse Clinical Trials

Explore recent trials published across the JAMA Network using keywords and curated filters.

Search & Browse