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TRIAL THEME OF THE MONTH
The Pragmatic Clinical Trial: Reconciling Intention, Design, and State of Mind
Alison J. Huang, MD, MAS; Thomas G. Travison, PhD; Derek C. Angus, MD, MPH
What makes a clinical trial a "pragmatic" trial? Since the concept of pragmatic trial research was introduced nearly 60 years ago, this label has been applied and interpreted beyond its original meaning. Today, pragmatic interventional research is characterized by definitional confusion and heterogeneity in how pragmatic design features are operationalized and justified.
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EDITOR’S CHOICE: CLINICAL TRIAL OF THE YEAR
Immune Modulation by Personalized vs Standard Prehabilitation Before Major Surgery: A Randomized Clinical Trial
Amélie Cambriel, MD; Amy Tsai, MD; Benjamin Choisy, MD; et al
Find out why JAMA Surgery Editor Dr Melina Kibbe thinks her trial pick of the year "provides a framework for the next generation of prehabilitation that is data driven, mechanism based, and patient specific."
Read the Editor's Note
GUIDE TO STATISTICS & METHODS FOR TRIALS
JAMA Guide to Statistics & Methods
Pragmatic Trials: Practical Answers to “Real World” Questions
Harold C. Sox, MD; Roger J. Lewis, MD, PhD
Audio / JAMA Guide to Statistics & Methods
The Intention-to-Treat Principle: Assessing the True Effect of Choosing a Treatment
Michelle A. Detry, PhD; Roger J. Lewis, MD, PhD
Research, Reviews, and Commentary
Original Investigation | JAMA Oncology
Federal and Industry Sponsorship in US Cancer Clinical Trials
Joseph M. Unger, PhD; Hong Xiao, PhD; Michael L. LeBlanc, PhD; et al
Research Letter | JAMA Network Open
Global Disparities in Current Clinical Trials in Cervical Cancer
Sneha Ahuja, BS; Carl Jay E. Jainar, MD; Sara Moufarrij, MD; et al
Editorial | JAMA
The Emperor’s New Clothes—The Discipline of Evidence
Spyridon P. Basourakos, MD; Jonathan E. Shoag, MD; Daniel E. Spratt, MD
Viewpoint | JAMA Oncology
Redefining Progression in a Rapidly Evolving Therapeutic Landscape
Neil Vasan, MD, PhD
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Explore recent trials published across the JAMA Network using keywords and curated filters.
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