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IN THIS ISSUE OF JAMA
Audio Highlights
Audio Editors' Summary: Platelet-Rich Plasma Injection for Knee Osteoarthritis, Bariatric Surgery for Nonalcoholic Steatohepatitis and Liver and Cardiac Outcomes, mRNA Vaccination and COVID-19 Hospitalizations, and more
ORIGINAL INVESTIGATION
Effect of Intra-articular Platelet-Rich Plasma vs Placebo Injection on Pain and Medial Tibial Cartilage Volume in Patients With Knee Osteoarthritis: The RESTORE Randomized Clinical Trial
Kim L. Bennell, PhD; Kade L. Paterson, PhD; Ben R. Metcalf, BSc; et al.
Earn CME credit
Editorial: Platelet-Rich Plasma for Osteoarthritis and Achilles Tendinitis; Jeffrey N. Katz, MD, MSc
Association of Bariatric Surgery With Major Adverse Liver and Cardiovascular Outcomes in Patients With Biopsy-Proven Nonalcoholic Steatohepatitis
Ali Aminian, MD; Abbas Al-Kurd, MD; Rickesha Wilson, MD; et al.
Earn CME credit
Editorial: Bariatric Surgery as a Strategy for Improving Outcomes in Nonalcoholic Steatohepatitis; Kathleen E. Corey, MD, MPH, MMSc; Zoe Nicole Memel, MD
Association Between mRNA Vaccination and COVID-19 Hospitalization and Disease Severity
Mark W. Tenforde, MD, PhD; Wesley H. Self, MD, MPH; Katherine Adams, MPH; et al.
Earn CME credit
Editorial: Understanding Breakthrough Infections Following mRNA SARS-CoV-2 Vaccination; Michael Klompas, MD, MPH
RESEARCH LETTER
Trends in Obesity Prevalence Among Adults Aged 18 Through 25 Years, 1976-2018
Alejandra Ellison-Barnes, MD, MPH; Sara Johnson, PhD, MPH; Kimberly Gudzune, MD, MPH
Incidence of Pancreatic Cancer by Age and Sex in the US, 2000-2018
Srinivas Gaddam, MD, MPH; Yazan Abboud, MD; Janice Oh, MD; et al.
VIEWPOINT
The Self-directed Medical Student Curriculum
Joseph H. Wu, PhD; Philip A. Gruppuso, MD; Eli Y. Adashi, MD, MS
Contraception Requirements in Clinical Trials: Considerations From Studies on Sexually Transmitted Infections
Jennifer E. Balkus, PhD; Jodie Dionne-Odom, MD; Harold C. Wiesenfeld, MD, CM
Twenty Years After the Anthrax Terrorist Attacks of 2001: Lessons Learned and Unlearned for the COVID-19 Response
Lawrence O. Gostin, JD; Jennifer B. Nuzzo, DrPH, SM
A PIECE OF MY MIND
Taking Down the Shingle
Diane Roston, MD
EDITORIAL
Platelet-Rich Plasma for Osteoarthritis and Achilles Tendinitis
Jeffrey N. Katz, MD, MSc
Bariatric Surgery as a Strategy for Improving Outcomes in Nonalcoholic Steatohepatitis
Kathleen E. Corey, MD, MPH, MMSc; Zoe Nicole Memel, MD
Understanding Breakthrough Infections Following mRNA SARS-CoV-2 Vaccination
Michael Klompas, MD, MPH
REVIEW
Management of Acne Vulgaris: A Review
Dawn Z. Eichenfield, MD, PhD; Jessica Sprague, MD; Lawrence F. Eichenfield, MD
Earn CME credit
Audio Clinical Review: Management of Acne Vulgaris
JAMA GUIDE TO STATISTICS AND METHODS
Use of Confidence Intervals in Interpreting Nonstatistically Significant Results
Alexander T. Hawkins, MD, MPH; Lauren R. Samuels, PhD
JAMA CLINICAL CHALLENGE
Back Pain, Fever, and Cough in a 46-Year-Old Man
Aaron Richterman, MD, MPH; Melissa Richard-Greenblatt, PhD; Kathryn Whitaker, MD
Earn CME credit
MEDICAL NEWS & PERSPECTIVES
Trials Test Mushrooms and Herbs as Anti–COVID-19 Agents
Anita Slomski
JAMA Medical News Audio: November 2021 Medical News Summary
NEWS FROM THE FOOD AND DRUG ADMINISTRATION
Compounded Drug Guidance for Hospital and Health System Pharmacies
Rita Rubin, MA
New Clinical Trial Grants for Rare Diseases
Rita Rubin, MA
First Thymus Tissue Product Approved for Rare Disease
Rita Rubin, MA
NEWS FROM THE CENTERS FOR DISEASE CONTROL AND PREVENTION
COVID-19 Vaccine Highly Effective Against Adolescent Hospitalizations
Bridget M. Kuehn, MSJ
Unhygienic Practices Lead to Routine Vaccination-Linked Infections
Bridget M. Kuehn, MSJ
CLINICAL TRIALS UPDATE
Pembrolizumab Boosts Breast and Cervical Cancer Survival
Anita Slomski
Daily COVID-19 Tests Compared With Isolation After School Exposure
Anita Slomski
Intensive Blood Pressure Control Lowers Cardiovascular Risk
Anita Slomski
Virtual Care Mitigates Pain and Drug Errors After Surgery
Anita Slomski
HEALTH AGENCIES UPDATE
Substance Use Disorders and COVID-19 Vaccine Response
Rita Rubin, MA
Support for Primary Care Clinicians in Underserved Areas
Rita Rubin, MA
The Cost of Rare Diseases
Rita Rubin, MA
POETRY AND MEDICINE
first death
Jordynn Klein, BAS
JAMA REVISITED
Bacterially Tainted Money
JAMA PATIENT PAGE
Acne Treatment
Raj Chovatiya, MD, PhD
Audio Clinical Review: Management of Acne Vulgaris
AUDIO
Audio Editors' Summary
Platelet-Rich Plasma Injection for Knee Osteoarthritis, Bariatric Surgery for Nonalcoholic Steatohepatitis and Liver and Cardiac Outcomes, mRNA Vaccination and COVID-19 Hospitalizations, and more
Audio Clinical Review
Management of Acne Vulgaris
JAMA Medical News Audio
November 2021 Medical News Summary
COMMENT & RESPONSE
Risk of N-Nitrosodimethylamine (NMDA) Formation With Ranitidine
David G. Strauss, MD, PhD; Jeffry Florian, PhD; David Keire, PhD
Risk of N-Nitrosodimethylamine (NMDA) Formation With Ranitidine—Reply
C. Michael White, PharmD; Adrian V. Hernandez, MD, PhD
The Role of Lipoprotein(a) in Cardiovascular Diseases
Margaret Nachtigall, MD; Richard H. Nachtigall, MD
The Role of Lipoprotein(a) in Cardiovascular Diseases—Reply
Pradeep Natarajan, MD, MMSc; Hannah Miksenas, BA; James L. Januzzi Jr, MD
Effect of 7 vs 14 Days of Antibiotics Among Afebrile Men With Urinary Tract Infection
Joel Goldberg, MD; John H. Powers III, MD
Effect of 7 vs 14 Days of Antibiotics Among Afebrile Men With Urinary Tract Infection
Sunn Hoah Kelvin Yap, BSc
Effect of 7 vs 14 Days of Antibiotics Among Afebrile Men With Urinary Tract Infection
Haroon Ahmed, PhD; David Gillespie, PhD; Emma Thomas-Jones, PhD
Effect of 7 vs 14 Days of Antibiotics Among Afebrile Men With Urinary Tract Infection—Reply
Dimitri M. Drekonja, MD, MS; Barbara Trautner, MD, PhD; James R. Johnson, MD
CORRECTION
Error in Box
Incorrect Laboratory Value and Reference
JAMA MASTHEAD
JAMA
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