| IN THIS ISSUE OF JAMAAudio Highlights Audio Editors' Summary: Monoclonal Antibodies for COVID-19, Strength Training for Knee OA, Metastatic Colorectal Cancer Review, and more ORIGINAL INVESTIGATIONEffect of Bamlanivimab as Monotherapy or in Combination With Etesevimab on Viral Load in Patients With Mild to Moderate COVID-19: A Randomized Clinical Trial Robert L. Gottlieb, MD, PhD; Ajay Nirula, MD, PhD; Peter Chen, MD; et al. Earn CME credit Editor's Note: Neutralizing Monoclonal Antibody for Mild to Moderate COVID-19; Preeti N. Malani, MD, MSJ; Robert M. Golub, MDEffect of High-Intensity Strength Training on Knee Pain and Knee Joint Compressive Forces Among Adults With Knee Osteoarthritis: The START Randomized Clinical Trial Stephen P. Messier, PhD; Shannon L. Mihalko, PhD; Daniel P. Beavers, PhD; et al. Earn CME creditAssociations of Maternal Cardiovascular Health in Pregnancy With Offspring Cardiovascular Health in Early Adolescence Amanda M. Perak, MD, MS; Nicola Lancki, MPH; Alan Kuang, MS; et al. Earn CME credit Editorial: Maternal Cardiovascular Health: A Critical Period for Offspring Lifetime Cardiovascular Health?; Stephen R. Daniels, MD, PhD RESEARCH LETTERChanges in Abortion in Texas Following an Executive Order Ban During the Coronavirus Pandemic Kari White, PhD, MPH; Bhavik Kumar, MD, MPH; Vinita Goyal, MD, MPH; et al. Earn CME credit VIEWPOINT Health PolicyA Blueprint for Comprehensive Medicaid Reform Rebekah E. Gee, MD, MPH; David Shulkin, MD; Iyah Romm, MD Conversations with Dr Bauchner: Health Care Reform in the Biden Era Health PolicyDeclining Life Expectancy in the United States: The Need for Social Policy as Health Policy Atheendar S. Venkataramani, MD, PhD; Rourke O’Brien, PhD; Alexander C. Tsai, MD, PhD Conversations with Dr Bauchner: Health Care Reform in the Biden EraRecalibrating the Use of Race in Medical Research John P. A. Ioannidis, MD, DSc; Neil R. Powe, MD, MPH, MBA; Clyde Yancy, MD, MSc Conversations with Dr Bauchner: Recalibrating the Use of Race in Medical ResearchRace and Pharmacogenomics—Personalized Medicine or Misguided Practice? Christopher W. Goodman, MD; Allan S. Brett, MDAddressing Systemic Racism Through Clinical Preventive Service Recommendations From the US Preventive Services Task Force Chyke A. Doubeni, MD, MPH; Melissa Simon, MD; Alex H. Krist, MD, MPH A PIECE OF MY MINDEnjoy the Vase Joseph S. Weiner, MD, PhD EDITORIALMaternal Cardiovascular Health: A Critical Period for Offspring Lifetime Cardiovascular Health? Stephen R. Daniels, MD, PhD REVIEWDiagnosis and Treatment of Metastatic Colorectal Cancer: A Review Leah H. Biller, MD; Deborah Schrag, MD, MPH Earn CME credit JAMA GUIDE TO STATISTICS AND METHODSImmortal Time Bias in Observational Studies Kabir Yadav, MDCM, MS, MSHS; Roger J. Lewis, MD, PhD JAMA INSIGHTSDiagnosis and Treatment of Anal Fissures in 2021 Yang Lu, MD; Mary R. Kwaan, MD, MPH; Anne Y. Lin, MD, MSHS EDITOR'S NOTENeutralizing Monoclonal Antibody for Mild to Moderate COVID-19 Preeti N. Malani, MD, MSJ; Robert M. Golub, MD Earn CME credit MEDICAL NEWS & PERSPECTIVES Quick UptakesHospital Clowns Ease Children’s Symptoms, Review Shows Mary Chris Jaklevic, MSJ NEWS FROM THE FOOD AND DRUG ADMINISTRATIONAdvice for n-of-1 Drug Developers Mary Chris Jaklevic, MSJGeneric Glucagon Approved for Severe Hypoglycemia Mary Chris Jaklevic, MSJMore Scrutiny for Laparoscopic Power Morcellator Procedures Mary Chris Jaklevic, MSJ GLOBAL HEALTHHigh-Income Countries Have Secured the Bulk of COVID-19 Vaccines Bridget M. Kuehn, MSJClinical Trials Overlook Diseases of Low-Income Countries Bridget M. Kuehn, MSJGlobal Partnership Aims to Improve Infant HIV Care Bridget M. Kuehn, MSJ POETRY AND MEDICINEHospital Vigil Janis Lou Harrington JAMA REVISITED Current Comment JAMA PATIENT PAGELateral Internal Sphincterotomy Yang Lu, MD; Anne Lin, MD, MSHS AUDIO Audio Editors' SummaryMonoclonal Antibodies for COVID-19, Strength Training for Knee OA, Metastatic Colorectal Cancer Review, and more COMMENT & RESPONSEWound Dressings for Obese Women After Cesarean Delivery Uyen G. Vo, MBBS; Toby Richards, MDWound Dressings for Obese Women After Cesarean Delivery—Reply Methodius G. Tuuli, MD, MPH; Lorie Harper, MD, MSCIThe Advantages of Medicare Advantage Samuel Metz, MDThe Advantages of Medicare Advantage—Reply Stuart M. Butler, PhDGeographic Differences in Uncontrolled Chronic Medical Conditions Erin L. Tompkins, MD, MPH; Joseph M. Maciuba, MD; Mary A. Andrews, MD, MPHGeographic Differences in Uncontrolled Chronic Medical Conditions—Reply Aaron Baum, PhD; Albert L. Siu, MD, MSPH; Mark D. Schwartz, MDDatabase Updates and Resulting Changes in Data in Study of Vaginal Mesh Hysteropexy vs Vaginal Hysterectomy Charles W. Nager, MD CORRECTION Error in Results Section JAMA MASTHEAD JAMA UPCOMING EVENT JAMA LivestreamCoronavirus Update With CDC Director Rochelle Walensky - February 17, 3:20pm Central US CDC Director Rochelle Walensky, MD, MPH returns to JAMA's Q&A series to discuss the agency's response to emerging variants, implications for the planned vaccine mobilization strategy, the upcoming J&J vaccine FDA advisory hearings, and other agency activities and priorities related to COVID19 control. 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