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IN THIS ISSUE OF JAMA
Audio Highlights
Audio Editors' Summary: Intravenous or Intraosseous Calcium for Out-of-Hospital Cardiac Arrest, Closure of Patent Foramen Ovale After Stroke, Clinical Outcomes in Preserved Ratio Impaired Spirometry, and more
ORIGINAL INVESTIGATION
Effect of Intravenous or Intraosseous Calcium vs Saline on Return of Spontaneous Circulation in Adults With Out-of-Hospital Cardiac Arrest: A Randomized Clinical Trial
Mikael Fink Vallentin, MD; Asger Granfeldt, MD, PhD, DMSc; Carsten Meilandt, BSc; et al.
Video: Effect of Intravenous or Intraosseous Calcium vs Saline on Return of Spontaneous Circulation in Adults With Out-of-Hospital Cardiac Arrest: A Randomized Clinical Trial
Heterogeneity of Treatment Effects in an Analysis of Pooled Individual Patient Data From Randomized Trials of Device Closure of Patent Foramen Ovale After Stroke
David M. Kent, MD, MS; Jeffrey L. Saver, MD; Scott E. Kasner, MD; et al.
Earn CME credit
Editorial: Patent Foramen Ovale Closure—Harnessing Clinical Trial Evidence to Inform Individualized Treatment Decisions; Robert W. Yeh, MD, MSc; Doreen DeFaria Yeh, MD
Association Between Preserved Ratio Impaired Spirometry and Clinical Outcomes in US Adults
Emily S. Wan, MD, MPH; Pallavi Balte, MBBS, PhD; Joseph E. Schwartz, PhD; et al.
Earn CME credit
RESEARCH LETTER
Association of Social Risk Factors With Home Dialysis and Kidney Transplant Rates in Dialysis Facilities
Rebecca Thorsness, PhD; Virginia Wang, PhD; Rachel E. Patzer, PhD, MPH; et al.
Frequency and Duration of Boarding for Pediatric Mental Health Conditions at Acute Care Hospitals in the US
JoAnna K. Leyenaar, MD, PhD, MPH; Seneca D. Freyleue, MS; Amy Bordogna, MPH; et al.
VIEWPOINT
Pediatric COVID-19 Vaccines: What Parents, Practitioners, and Policy Makers Need to Know
William J. Moss, MD, MPH; Lawrence O. Gostin, JD; Jennifer B. Nuzzo, DrPH, SM
Incentivizing a New Culture of Data Stewardship: The NIH Policy for Data Management and Sharing
Lyric A. Jorgenson, PhD; Carrie D. Wolinetz, PhD; Francis S. Collins, MD, PhD
Contextualizing Risk Among Patients With Heart Failure
Stephen J. Greene, MD; Javed Butler, MD, MPH, MBA; Gregg C. Fonarow, MD
A PIECE OF MY MIND
The Hardest Thing
Vidya Bhavani Viswanathan, MD
EDITORIAL
Patent Foramen Ovale Closure—Harnessing Clinical Trial Evidence to Inform Individualized Treatment Decisions
Robert W. Yeh, MD, MSc; Doreen DeFaria Yeh, MD
REVIEW
Diagnosis and Management of Acute Appendicitis in Adults: A Review
Dimitrios Moris, MD, MSc, PhD; Erik Karl Paulson, MD; Theodore N. Pappas, MD
Earn CME credit
Audio Clinical Review: Current Management of Acute Appendicitis: Antibiotics or Surgical Intervention
JAMA GUIDE TO STATISTICS AND METHODS
Heterogeneity of Treatment Effect: Estimating How the Effects of Interventions Vary Across Individuals
Derek C. Angus, MD, MPH; Chung-Chou H. Chang, PhD
JAMA CLINICAL CHALLENGE
Erythematous Papules and Hemorrhagic Vesicles in a Woman With Arthralgias and Eye Pain
Lindsey West, MD; Sung Kyung Cho, BA; Cristina Thomas, MD
Earn CME credit
MEDICAL NEWS & PERSPECTIVES
COVID-19 Vaccine Makers Plan for Annual Boosters, but It’s Not Clear They’ll Be Needed
Rita Rubin, MA
NEWS FROM THE CENTERS FOR DISEASE CONTROL AND PREVENTION
Cancer Care Creates Substantial Costs for US Patients
Bridget M. Kuehn, MSJ
Delta Variant Wasn’t Linked With More Severe Disease
Bridget M. Kuehn, MSJ
BIOTECH INNOVATIONS
Data Emerge From the UK’s COVID-19 Vaccine Extended Dosing Interval
Jennifer Abbasi
COVID-19 Vaccine Combination Was Superior in Real-world Study
Jennifer Abbasi
Immunocompromised Patients With COVID-19 Receive Interferon Gamma
Jennifer Abbasi
THE ARTS AND MEDICINE
The Legacy of James McCune Smith, MD—The First US Black Physician
Neil Krishan Aggarwal, MD, MBA
POETRY AND MEDICINE
In a Dark Wood
Michael Wynn, DO
JAMA REVISITED
Myth and Mumpsimus in Medicine
JAMA PATIENT PAGE
Acute Appendicitis
Kristin Walter, MD, MS
AUDIO
Audio Editors' Summary
Intravenous or Intraosseous Calcium for Out-of-Hospital Cardiac Arrest, Closure of Patent Foramen Ovale After Stroke, Clinical Outcomes in Preserved Ratio Impaired Spirometry, and more
Audio Clinical Review
Current Management of Acute Appendicitis: Antibiotics or Surgical Intervention
VIDEO
Effect of Intravenous or Intraosseous Calcium vs Saline on Return of Spontaneous Circulation in Adults With Out-of-Hospital Cardiac Arrest: A Randomized Clinical Trial
COMMENT & RESPONSE
Sedation and Ventilator Liberation Protocol vs Usual Care and Duration of Invasive Ventilation in Pediatric Intensive Care Units
Nobuyuki Nosaka, MD, PhD; Takahiro Masuda, MD
Sedation and Ventilator Liberation Protocol vs Usual Care and Duration of Invasive Ventilation in Pediatric Intensive Care Units—Reply
Bronagh Blackwood, PhD; Daniel F. McAuley, MD; Mark J. Peters, PhD
Active vs Expectant Management of Persisting Pregnancy of Unknown Location
Jian-Rong He, MD; Hui-Yun Xiao, MD; Xiu Qiu, PhD
Active vs Expectant Management of Persisting Pregnancy of Unknown Location—Reply
Kurt T. Barnhart, MD, MSCE; Anne Z. Steiner, MD; Karl R. Hansen, MD, PhD
Nicotine Pouch Unit Sales in the US From 2016 to 2020
Mary Hrywna, PhD, MPH; M. Jane Lewis, DrPH; Pamela M. Ling, MD, MPH
Nicotine Pouch Unit Sales in the US From 2016 to 2020—Reply
Kristy Marynak, MPP; Sherry Emery, PhD; Brian A. King, PhD, MPH
Slower vs Faster Intravenous Fluid Bolus Rates and Mortality in Critically Ill Patients
Xavier Chapalain, MD; Olivier Huet, MD, PhD
Slower vs Faster Intravenous Fluid Bolus Rates and Mortality in Critically Ill Patients—Reply
Fernando G. Zampieri, MD, PhD; Alexandre B. Cavalcanti, MD, PhD
CORRECTION
Erroneous Terminology in Review
Incorrect Wording in 2 Places
JAMA MASTHEAD
JAMA
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