|
IN THIS ISSUE OF JAMA
Audio Highlights
Audio Summary: Drug Pricing Theme Issue: Is Pharma Earning Too Much?, R&D Costs Required to Bring a New Drug to Market, Probiotic Safety, and more
COVID-19
Epidemiologic Features and Clinical Course of Patients Infected With SARS-CoV-2 in Singapore
Barnaby Edward Young, MB, BChir; Sean Wei Xiang Ong, MBBS; Shirin Kalimuddin, MPH; et al.
Response to COVID-19 in Taiwan: Big Data Analytics, New Technology, and Proactive Testing
C. Jason Wang, MD, PhD; Chun Y. Ng, MBA, MPH; Robert H. Brook, MD, ScD
Priorities for the US Health Community Responding to COVID-19
Amesh A. Adalja, MD; Eric Toner, MD; Thomas V. Inglesby, MD
ORIGINAL INVESTIGATION
Profitability of Large Pharmaceutical Companies Compared With Other Large Public Companies
Fred D. Ledley, MD; Sarah Shonka McCoy, PhD; Gregory Vaughan, PhD; et al.
Earn CME credit
Editorial: Relentless Prescription Drug Price Increases; Chaarushena Deb; Gregory Curfman, MD
Editorial: Are Pharmaceutical Companies Earning Too Much?; David M. Cutler, PhD
Editorial: Affording Medicines for Today’s Patients and Sustaining Innovation for Tomorrow; Kenneth C. Frazier, JD
Estimated Research and Development Investment Needed to Bring a New Medicine to Market, 2009-2018
Olivier J. Wouters, PhD; Martin McKee, MD, DSc; Jeroen Luyten, PhD
Earn CME credit
Changes in List Prices, Net Prices, and Discounts for Branded Drugs in the US, 2007-2018
Inmaculada Hernandez, PharmD, PhD; Alvaro San-Juan-Rodriguez, PharmD; Chester B. Good, MD, MPH; et al.
US Health Care Spending by Payer and Health Condition, 1996-2016
Joseph L. Dieleman, PhD; Jackie Cao, MS; Abby Chapin, BA; et al.
Earn CME credit
RESEARCH LETTER
Sponsorship and Funding for Gene Therapy Trials in the United States
Zachary Kassir, BA; Ameet Sarpatwari, PhD, JD; Brian Kocak, BS; et al.
VIEWPOINT
Drug Shortages in the United States: Are Some Prices Too Low?
Inmaculada Hernandez, PharmD, PhD; Tina Batra Hershey, JD, MPH; Julie M. Donohue, PhD
Expanding Access and Reducing Prices for Drugs to Prevent HIV: Should Government Enforce Its Patent Rights Against the Pharmaceutical Industry?
Lawrence O. Gostin, JD; Arti K. Rai, JD
The Probiotic Conundrum: Regulatory Confusion, Conflicting Studies, and Safety Concerns
Stephen B. Freedman, MDCM, MSc; David Schnadower, MD, MPH; Phillip I. Tarr, MD
A PIECE OF MY MIND
The Secret About Achieving Your Dreams
Adam Philip Stern, MD
EDITORIAL
Relentless Prescription Drug Price Increases
Chaarushena Deb; Gregory Curfman, MD
Are Pharmaceutical Companies Earning Too Much?
David M. Cutler, PhD
Affording Medicines for Today’s Patients and Sustaining Innovation for Tomorrow
Kenneth C. Frazier, JD
JAMA CLINICAL GUIDELINES SYNOPSIS
Diagnosis and Treatment of Adults With Community-Acquired Pneumonia
Gregory Olson, MD; Andrew M. Davis, MD, MPH
FROM THE MEDICAL LETTER ON DRUGS AND THERAPEUTICS
Corticosteroids in Community-Acquired Pneumonia
MEDICAL NEWS & PERSPECTIVES
Rebates—The Little-Known Factor Behind Increasing Drug List Prices
Rita Rubin, MA
NEWS FROM THE FOOD AND DRUG ADMINISTRATION
FDA Policies Address Development of Gene Therapies
Rebecca Voelker, MSJ
New Nonsurgical Option Approved for Thyroid Eye Disease
Rebecca Voelker, MSJ
Drug Approved to Aid Youths With Peanut Allergy
Rebecca Voelker, MSJ
THE JAMA FORUM
Rising Prices and Health Care “Empires”
Andrew B. Bindman, MD
BENCH TO BEDSIDE
New Insight on Preventing EGFR Inhibitor–Induced Adverse Effects
Tracy Hampton, PhD
POETRY AND MEDICINE
After a Long Illness
Judith Harris
JAMA REVISITED
Toxics
JAMA PATIENT PAGE
“Surprise” Out-of-Network Medical Bills
Karan R. Chhabra, MD, MSc; Justin B. Dimick, MD, MPH
AUDIO
Audio Summary
Drug Pricing Theme Issue: Is Pharma Earning Too Much?, R&D Costs Required to Bring a New Drug to Market, Probiotic Safety, and more
COMMENT & RESPONSE
Strategies to Avoid Extubation Failure Among ICU Patients
Wataru Matsuda, MD
Strategies to Avoid Extubation Failure Among ICU Patients—Reply
Arnaud W. Thille, MD, PhD; Stéphanie Ragot, PharmD, PhD; Jean-Pierre Frat, MD
Informed Consent for Stem Cell–Based Interventions
Zubin Master, PhD; Cambray Smith, BS; Jon C. Tilburt, MD, MPH
Informed Consent for Stem Cell–Based Interventions—Reply
R. Alta Charo, JD; Roger A. Barker, MRCP, PhD; Jeremy Sugarman, MD, MPH, MA
Wasteful Health Care Spending in the United States
Edward W. Martin, MD, MPH; John B. Murphy, MD; Richard W. Besdine, MD
Wasteful Health Care Spending in the United States
John W. Urwin, MD; Peter J. Pronovost, MD, PhD; Amol S. Navathe, MD, PhD
Wasteful Health Care Spending in the United States—Reply
William H. Shrank, MD, MSHS; Natasha Parekh, MD, MS
CORRECTION
Incorrect Wording
JAMA MASTHEAD
JAMA
|
