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IN THIS ISSUE OF JAMA
Audio Highlights
Audio Editors' Summary: Baclofen for ICU Alcohol Withdrawal, Vitamin C and Thiamine for Sepsis, Multiple Sclerosis Review, and more
ORIGINAL INVESTIGATION
Effect of High-Dose Baclofen on Agitation-Related Events Among Patients With Unhealthy Alcohol Use Receiving Mechanical Ventilation: A Randomized Clinical Trial
Mickael Vourc’h, MD; Charlotte Garret, MD; Arnaud Gacouin, MD; et al.
Editorial: Baclofen to Prevent Agitation Caused by Alcohol Withdrawal in the ICU; Michael C. Reade, MBBS, DPhil
Video: Effect of Baclofen on Agitation-Related Events Among Mechanically Ventilated Patients With Alcohol Use Disorder
Caring for the Critically Ill Patient
Effect of Vitamin C, Thiamine, and Hydrocortisone on Ventilator- and Vasopressor-Free Days in Patients With Sepsis: The VICTAS Randomized Clinical Trial
Jonathan E. Sevransky, MD, MHS; Richard E. Rothman, MD, PhD; David N. Hager, MD, PhD; et al.
Earn CME credit
Editorial: Hydrocortisone, Vitamin C, and Thiamine for Treatment of Sepsis: Making Evidence Matter; Kristin L. Walter, MD, MS; Christopher W. Seymour, MD, MSc
Editor's Note: Funding and DSMB Membership in the VICTAS Clinical Trial; Howard Bauchner, MD; Phil B. Fontanarosa, MD, MBA; Robert M. Golub, MD
Association of Rare CYP39A1 Variants With Exfoliation Syndrome Involving the Anterior Chamber of the Eye
The Genetics of Exfoliation Syndrome Partnership
Earn CME credit
RESEARCH LETTER
All-Cause Excess Mortality and COVID-19–Related Mortality Among US Adults Aged 25-44 Years, March-July 2020
Jeremy Samuel Faust, MD, MS; Harlan M. Krumholz, MD, SM; Chengan Du, PhD; et al.
Earn CME credit
Conversations with Dr Bauchner: Coronavirus Update With CDC Director Rochelle Walensky
VIEWPOINT
Health Policy
Surprise Billing—A Flashpoint for Major Policy Issues in Health Care
Carrie Colla, PhD
Conversations with Dr Bauchner: Health Care Reform in the Biden Era
Health Policy
From Digitization to Digital Transformation: Policy Priorities for Closing the Gap
Julia Adler-Milstein, PhD
Conversations with Dr Bauchner: Health Care Reform in the Biden Era
Racial and Ethnic Health Disparities Related to COVID-19
Leo Lopez III, MD, MHS; Louis H. Hart III, MD; Mitchell H. Katz, MD
Earn CME credit
Audio Clinical Review: Racial and Ethnic Disparities in COVID-19
A Viral Pandemic, Vaccine Safety, and Compensation for Adverse Events
H. Cody Meissner, MD
Conversations with Dr Bauchner: COVID-19 Vaccine Approval and the FDA
When Physicians Engage in Practices That Threaten the Nation’s Health
Philip A. Pizzo, MD; David Spiegel, MD; Michelle M. Mello, JD, PhD
Conversations with Dr Bauchner: When Physicians Engage in Practices That Threaten the Nation’s Health
A PIECE OF MY MIND
COVID-19 Communication—The Need for Humanity, Empathy, and Grace
Lisa M. Meeks, PhD
EDITORIAL
Baclofen to Prevent Agitation Caused by Alcohol Withdrawal in the ICU
Michael C. Reade, MBBS, DPhil
Hydrocortisone, Vitamin C, and Thiamine for Treatment of Sepsis: Making Evidence Matter
Kristin L. Walter, MD, MS; Christopher W. Seymour, MD, MSc
REVIEW
Diagnosis and Treatment of Multiple Sclerosis: A Review
Marisa P. McGinley, DO; Carolyn H. Goldschmidt, DO; Alexander D. Rae-Grant, MD
Earn CME credit
Audio Clinical Review: Diagnosis and Treatment of Multiple Sclerosis—A Review
JAMA INSIGHTS
Clinical Update
Allergic Reactions Including Anaphylaxis After Receipt of the First Dose of Pfizer-BioNTech COVID-19 Vaccine
Tom Shimabukuro, MD, MPH, MBA; Narayan Nair, MD
Earn CME credit
Audio Clinical Review: COVID-19 Vaccine Safety–Anaphylaxis and Allergic Reactions
JAMA CLINICAL CHALLENGE
A Purpuric Rash
Kevin D. He, MD; Ken He, MD; Paul B. Cornia, MD
Earn CME credit
EDITOR'S NOTE
Funding and DSMB Membership in the VICTAS Clinical Trial
Howard Bauchner, MD; Phil B. Fontanarosa, MD, MBA; Robert M. Golub, MD
MEDICAL NEWS & PERSPECTIVES
“Important Conversations” Are Needed to Explain the Nocebo Effect
Anita Slomski, MA
JAMA Medical News Audio: February 2021 Medical News Summary
JAMA Medical News Audio: Live from AHA 2020: Highlights from the American Heart Association’s Virtual Scientific Sessions
THE JAMA FORUM
From Economic Recovery to Health Resilience
Dave A. Chokshi, MD, MSc
NEWS FROM THE CENTERS FOR DISEASE CONTROL AND PREVENTION
COVID-19 Rates Increased Where In-Person College Classes Were Held
Bridget M. Kuehn, MSJ
Drug-Resistant Yeast Infections Spread in COVID-19 Unit
Bridget M. Kuehn, MSJ
CLINICAL TRIALS UPDATE
Oral Rimegepant Safe, Effective for Migraine Prevention
Anita Slomski, MA
Finerenone for Patients With CKD and Type 2 Diabetes
Anita Slomski, MA
Common Weight Loss Surgeries’ Benefits Sustained at Year 7
Anita Slomski, MA
Navigators Improve Autism Evaluations but Not Referrals to Care
Anita Slomski, MA
Physician Videos Improve COVID-19 Knowledge Among Minorities
Anita Slomski, MA
HEALTH AGENCIES UPDATE
Collecting Data About COVID-19–Related Brain Symptoms
Rita Rubin, MA
Detecting Heart Transplant Rejection Earlier, More Easily
Rita Rubin, MA
Locating COVID-19 Monoclonal Antibody Therapies
Rita Rubin, MA
POETRY AND MEDICINE
Knows
Mark Dow
JAMA REVISITED
The Worth of a Miracle
JAMA PATIENT PAGE
Nystagmus
Malcolm M. Kates, BS, BA; Casey J. Beal, MD
AUDIO
Audio Editors' Summary
Baclofen for ICU Alcohol Withdrawal, Vitamin C and Thiamine for Sepsis, Multiple Sclerosis Review, and more
Conversations with Dr Bauchner
Coronavirus Update With CDC Director Rochelle Walensky
Audio Clinical Review
COVID-19 Vaccine Safety–Anaphylaxis and Allergic Reactions
JAMA Medical News Audio
February 2021 Medical News Summary
VIDEO
Effect of Baclofen on Agitation-Related Events Among Mechanically Ventilated Patients With Alcohol Use Disorder
Karim Asehnoune, MD, PhD, and Mickael Vourc’h, MD, of CHU de Nantes in Nantes, France present findings from the BACLOREA Trial at the virtual Critical Care Reviews Meeting 2021 (CCR21) on January 21, 2021. An oral editorial from Waleed Alhazzani of McMaster University and a Q&A session follow.
COMMENT & RESPONSE
Risk of Spinal Hematoma After Lumbar Puncture
Tao Xu, PhD; You Wang, MD; Yangmei Chen, PhD
Risk of Spinal Hematoma After Lumbar Puncture
Chloe Kimi Nobuhara, BS; Miles Berger, MD, PhD
Risk of Spinal Hematoma After Lumbar Puncture—Reply
Jacob Bodilsen, MD, PhD; Henrik Nielsen, MD, DMSci
The Effect of Surgical Treatment on Obstructive Sleep Apnea
Vanessa Alderman, MBBS; Joshua Agbetile, MD
The Effect of Surgical Treatment on Obstructive Sleep Apnea—Reply
Stuart MacKay, MD; R. Doug McEvoy, MD; Edward M. Weaver, MD, MPH
Cervical Cancer Screening in Low- and Middle-Income Countries
Miriam Cremer, MD, MPH; Karla Alfaro, MD, MPH; Rachel Masch, MD, MPH
Cervical Cancer Screening in Low- and Middle-Income Countries—Reply
Pascal Geldsetzer, MBChB, ScD, MPH; Julia M. Lemp, MSc
JAMA MASTHEAD
JAMA
UPCOMING EVENT
JAMA Livestream
Coronavirus Update With Nancy E. Messonnier, Feb 26 11:20am Central US
Nancy Messonier is Director of the National Center for Immunization and Respiratory Diseases (NCIRD) at the Centers for Disease Control and Prevention (CDC) and leads the CDC’s efforts on COVID-19 vaccine. She joins JAMA's Q&A series to discuss the agency's response to emerging coronavirus variants, the FDA advisory hearings on the new Johnson & Johnson vaccine, strategies for reopening K-12 schools, and other agency activities and priorities related to COVID-19 control.
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