IN THIS ISSUE OF JAMA
Audio Highlights
Audio Summary: Epigenetic Therapy for ACS, Convalescent Serum for COVID-19, USPSTF Guideline for Smoking Cessation in Adolescents, and more
ORIGINAL INVESTIGATION
Effect of Apabetalone Added to Standard Therapy on Major Adverse Cardiovascular Events in Patients With Recent Acute Coronary Syndrome and Type 2 Diabetes: A Randomized Clinical Trial
Kausik K. Ray, MBChB; Stephen J. Nicholls, MBBS, PhD; Kevin A. Buhr, PhD; et al.
Earn CME credit
Editorial: Epigenetic Therapeutics for Cardiovascular Disease: Writing, Erasing, Reading, and Maybe Forgetting; Jorge Plutzky, MD
Baseline Characteristics and Outcomes of 1591 Patients Infected With SARS-CoV-2 Admitted to ICUs of the Lombardy Region, Italy
Giacomo Grasselli, MD; Alberto Zangrillo, MD; Alberto Zanella, MD; et al.
Earn CME credit
Editorial: Critical Illness in Patients With COVID-19: Mounting an Effective Clinical and Research Response; Deborah J. Cook, MD, MSc; John C. Marshall, MD; Robert A. Fowler, MDCM, MS
PRELIMINARY COMMUNICATION
Treatment of 5 Critically Ill Patients With COVID-19 With Convalescent Plasma
Chenguang Shen, PhD; Zhaoqin Wang, PhD; Fang Zhao, PhD; et al.
Earn CME credit
Editorial: Convalescent Plasma to Treat COVID-19: Possibilities and Challenges; John D. Roback, MD, PhD; Jeannette Guarner, MD
RESEARCH LETTER
Air, Surface Environmental, and Personal Protective Equipment Contamination by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) From a Symptomatic Patient
Sean Wei Xiang Ong, MBBS; Yian Kim Tan, PhD; Po Ying Chia, MBBS; et al.
Earn CME credit
Characteristics and Outcomes of 21 Critically Ill Patients With COVID-19 in Washington State
Matt Arentz, MD; Eric Yim, MD; Lindy Klaff, MD; et al.
Clinical Review Audio: COVID-19 in Seattle: Clinical Features and Managing the Outbreak
Quality Measure Development and Associated Spending by the Centers for Medicare & Medicaid Services
Rishi K. Wadhera, MD, MPP, MPhil; Jose F. Figueroa, MD, MPH; Karen E. Joynt Maddox, MD, MPH; et al.
US PREVENTIVE SERVICES TASK FORCE
Recommendation Statement
Primary Care Interventions for Prevention and Cessation of Tobacco Use in Children and Adolescents: US Preventive Services Task Force Recommendation Statement
US Preventive Services Task Force
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Editorial: Recommendations From the USPSTF for Prevention and Cessation of Tobacco Use in Children and Adolescents; James D. Sargent, MD; Jennifer B. Unger, PhD; Adam M. Leventhal, PhD
Audio Interview: USPSTF Recommendation: Tobacco Use Prevention and Cessation in Children and Adolescents
Evidence Report
Primary Care–Relevant Interventions for Tobacco and Nicotine Use Prevention and Cessation in Children and Adolescents: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force
Shelley Selph, MD, MPH; Carrie Patnode, PhD, MPH; Steffani R. Bailey, PhD; et al.
Editorial: Recommendations From the USPSTF for Prevention and Cessation of Tobacco Use in Children and Adolescents; James D. Sargent, MD; Jennifer B. Unger, PhD; Adam M. Leventhal, PhD
Audio Interview: USPSTF Recommendation: Tobacco Use Prevention and Cessation in Children and Adolescents
VIEWPOINT
Critical Care Utilization for the COVID-19 Outbreak in Lombardy, Italy: Early Experience and Forecast During an Emergency Response
Giacomo Grasselli, MD; Antonio Pesenti, MD; Maurizio Cecconi, MD
Earn CME credit
Audio Interview: Coronavirus in Italy—Report From the Front Lines
Presidential Powers and Response to COVID-19
Lawrence O. Gostin, JD; James G. Hodge Jr, JD, LLM; Lindsay F. Wiley, JD, MPH
Managing COVID-19 in Low- and Middle-Income Countries
Joost Hopman, MD, PhD, DTMH; Benedetta Allegranzi, MD, DTMH; Shaheen Mehtar, MBBS, MD (Lon)
Earn CME credit
The Role of Physicians in Addressing Social Determinants of Health
Nason Maani, PhD; Sandro Galea, MD, DrPH
Audio Interview: The Role of Physicians in Addressing Social Determinants of Health
Addressing Social Determinants of Health: Time for a Polysocial Risk Score
Jose F. Figueroa, MD, MPH; Austin B. Frakt, PhD; Ashish K. Jha, MD, MPH
A PIECE OF MY MIND
Personal Risk and Societal Obligation Amidst COVID-19
Cynthia Tsai, MD
Earn CME credit
Editorial: Health Care Heroes of the COVID-19 Pandemic; Howard Bauchner, MD; Thomas J. Easley; on behalf of the entire editorial and publishing staff of JAMA and the JAMA Network
EDITORIAL
Epigenetic Therapeutics for Cardiovascular Disease: Writing, Erasing, Reading, and Maybe Forgetting
Jorge Plutzky, MD
Critical Illness in Patients With COVID-19: Mounting an Effective Clinical and Research Response
Deborah J. Cook, MD, MSc; John C. Marshall, MD; Robert A. Fowler, MDCM, MS
Earn CME credit
Convalescent Plasma to Treat COVID-19: Possibilities and Challenges
John D. Roback, MD, PhD; Jeannette Guarner, MD
Earn CME credit
Recommendations From the USPSTF for Prevention and Cessation of Tobacco Use in Children and Adolescents
James D. Sargent, MD; Jennifer B. Unger, PhD; Adam M. Leventhal, PhD
Audio Interview: USPSTF Recommendation: Tobacco Use Prevention and Cessation in Children and Adolescents
MEDICAL NEWS & PERSPECTIVES
With First CRISPR Trials, Gene Editing Moves Toward the Clinic
Tracy Hampton, PhD
Medical News Audio: April 2020 Medical News Summary
Quick Uptakes
Coconut Oil’s Health Halo a Mirage, Clinical Trials Suggest
Jennifer Abbasi
NEWS FROM THE CENTERS FOR DISEASE CONTROL AND PREVENTION
Head Injury Deaths on the Rise
Bridget M. Kuehn, MSJ
New York Hospital Was Likely Source of Young Man’s HIV Infection
Bridget M. Kuehn, MSJ
CLINICAL TRIALS UPDATE
Long-Acting Injectable HIV Therapy Noninferior to Daily Pills
Anita Slomski, MA
Methotrexate and Adverse Events in CIRT Secondary Analysis
Anita Slomski, MA
Limiting Vulnerable Infants’ Secondhand Smoke Exposure
Anita Slomski, MA
Palliative Care Benefits Patients With Parkinson Disease
Anita Slomski, MA
Alteplase Inhibits Nerinetide, a Novel Stroke Drug
Anita Slomski, MA
HEALTH AGENCIES UPDATE
Using 2 Prostate Biopsy Techniques Optimizes Cancer Diagnosis
Rita Rubin, MA
New AHRQ Patient Safety Guidance
Rita Rubin, MA
Lower Out-of-Pocket Insulin Costs for Medicare Plan D Beneficiaries
Rita Rubin, MA
POETRY AND MEDICINE
Thangkhali Hospital at Night II
Andrew Dimitri, MBBS (hons), BSc (med)
JAMA REVISITED
The Influenza Outbreak
JAMA PATIENT PAGE
Preventing Tobacco Use in Children and Adolescents
Angel N. Desai, MD, MPH
Audio Interview: USPSTF Recommendation: Tobacco Use Prevention and Cessation in Children and Adolescents
AUDIO
Audio Summary
Epigenetic Therapy for ACS, Convalescent Serum for COVID-19, USPSTF Guideline for Smoking Cessation in Adolescents, and more
Clinical Review Audio
COVID-19 in Seattle: Clinical Features and Managing the Outbreak
Audio Interview
Coronavirus in Italy—Report From the Front Lines
Audio Interview
The Role of Physicians in Addressing Social Determinants of Health
Medical News Audio
April 2020 Medical News Summary
COMMENT & RESPONSE
Premature Menopause and Risk for Cardiovascular Disease
Pierre Yves Scarabin, MD, MSc
Premature Menopause and Risk for Cardiovascular Disease
Xianshi Zhou, MD; Guanghua Tang, PhD
Premature Menopause and Risk for Cardiovascular Disease—Reply
Michael C. Honigberg, MD, MPP; Pradeep Natarajan, MD, MMSc
Health Outcomes With Vitamin D Supplementation
William B. Grant, PhD; Barbara J. Boucher, MD
Health Outcomes With Vitamin D Supplementation—Reply
Anika Lucas, MD; Myles Wolf, MD, MMSc
CORRECTION
Typographical Error
Data Error in Viewpoint on COVID-19 in Italy
JAMA MASTHEAD
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