The path of nCoV cell penetration

New research shows that nCoV attacks patient's cells through the ACE2 receptor, similar to the virus that causes the SARS epidemic.

The team at the University of Minnesota and the University of North Carolina analyzed receptors that nCoV is capable of using to invade cells, Sci-News reported yesterday. They conducted a new study based on information on SARS-CoV, the virus that causes Severe Acute Respiratory Failure Syndrome, and the newly published gene sequence of nCoV. The research was published in the Journal of Virology, the journal of the American Society of Microbiology.

"The emergence of 2019-nCoV has recently put the world on alert. The new pneumonia epidemic is reminiscent of the SARS epidemic in 2002-2003," said Fang Li, PhD in the Department of Biomedical and Veterinary Science. University of Minnesota, together with colleagues.

"Our many years of structural studies have shown how SARS-CoV interacts with human and animal hosts to infect. The mechanism of nCoV infection appears to be similar," the team said. said rescue.

Dr. Li and his team of experts used information obtained from samples of SARS-CoV isolated from multiple hosts over different years and angiotensin-2 converting enzyme (ACE2) receptors from different animals to Modeling predictions about the new corona virus.

According to the team's structural analysis, nCoV enters cells via the ACE2 receptor, just like SARS-CoV. This and some of the other structural details about nCoV are suitable for the ability to be transmitted to humans, even from person to person.

"Remarkably, our data predict that a single mutation, at a specific site in the genome, could significantly enhance nCoV's ability to bind to human ACE2 receptors. NCoV evolution should be closely monitored in patients for new mutations at position 501 in the genome and, to a lesser extent, position 494, to predict possible disease outbreaks. more serious, "the team said.

Thu Thao (According to Sci-News)

Nguồn: vnexpress.net