New Issue: Low Tidal Volume Mechanical Ventilation Using ECCO2R, Probiotics to Prevent VAP in the ICU, TAVR for Bicuspid Aortic Stenosis, Medical Schools in the US, and more

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New Issue

SEPTEMBER 21, 2021; VOLUME 326, NUMBER 11
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IN THIS ISSUE OF JAMA

Audio Highlights

Audio Editors' Summary: Low Tidal Volume Mechanical Ventilation Using ECCO2R, Probiotics to Prevent VAP in the ICU, TAVR for Bicuspid Aortic Stenosis, Medical Schools in the US, and more

ORIGINAL INVESTIGATION

Caring for the Critically Ill Patient

Effect of Lower Tidal Volume Ventilation Facilitated by Extracorporeal Carbon Dioxide Removal vs Standard Care Ventilation on 90-Day Mortality in Patients With Acute Hypoxemic Respiratory Failure: The REST Randomized Clinical Trial

James J. McNamee, MB, ChB; Michael A. Gillies, MD; Nicholas A. Barrett, MB, ChB; et al.

Effect of Probiotics on Incident Ventilator-Associated Pneumonia in Critically Ill Patients: A Randomized Clinical Trial

Jennie Johnstone, MD, PhD; Maureen Meade, MD, MSc; François Lauzier, MD, MSc; et al.

Earn CME credit

Association Between Transcatheter Aortic Valve Replacement for Bicuspid vs Tricuspid Aortic Stenosis and Mortality or Stroke Among Patients at Low Surgical Risk

Raj R. Makkar, MD; Sung-Han Yoon, MD; Tarun Chakravarty, MD; et al.

Editorial: Transcatheter Valve Replacement for Bicuspid Aortic Stenosis; Catherine M. Otto, MD; David E. Newby, MD

RESEARCH LETTER

Antibody Response After a Third Dose of the mRNA-1273 SARS-CoV-2 Vaccine in Kidney Transplant Recipients With Minimal Serologic Response to 2 Doses

Ilies Benotmane, MD; Gabriela Gautier, MD; Peggy Perrin, MD; et al.

Earn CME credit

Change in Saliva RT-PCR Sensitivity Over the Course of SARS-CoV-2 Infection

Zion Congrave-Wilson, MS; Yesun Lee, PhD; Jaycee Jumarang, MD; et al.

Earn CME credit

SPECIAL COMMUNICATION

A Guideline for Reporting Mediation Analyses of Randomized Trials and Observational Studies: The AGReMA Statement

Hopin Lee, PhD; Aidan G. Cashin, PhD; Sarah E. Lamb, DPhil; et al.

Earn CME credit

Editorial: A Reporting Guideline for Mediation Analyses; Kabir Yadav, MDCM, MS, MSHS; Roger J. Lewis, MD, PhD

Editor’s Note: Reporting Findings From Mediation Analyses; Phil B. Fontanarosa, MD, MBA

VIEWPOINT

Confronting the Delta Variant of SARS-CoV-2, Summer 2021

Carlos del Rio, MD; Preeti N. Malani, MD, MSJ; Saad B. Omer, MBBS, PhD

Earn CME credit

Video: Frequently Asked COVID-19 Vaccine Questions

Video: Immunosuppression, Chronic COVID-19, and SARS-CoV-2 Variants

Potential Implications of SARS-CoV-2 Delta Variant Surges for Rural Areas and Hospitals

Sameer S. Kadri, MD, MS; Steven Q. Simpson, MD

Video: Frequently Asked COVID-19 Vaccine Questions

The Helping to End Addiction Long-term (HEAL) Initiative of the National Institutes of Health

Rebecca G. Baker, PhD; Walter J. Koroshetz, MD; Nora D. Volkow, MD

A PIECE OF MY MIND

It Is What It Is

Meeta Prasad Kerlin, MD, MSCE

EDITORIAL

Transcatheter Valve Replacement for Bicuspid Aortic Stenosis

Catherine M. Otto, MD; David E. Newby, MD

A Reporting Guideline for Mediation Analyses

Kabir Yadav, MDCM, MS, MSHS; Roger J. Lewis, MD, PhD

JAMA CLINICAL GUIDELINES SYNOPSIS

Recommendations for Prevention and Management of Chemotherapy-Induced Peripheral Neuropathy

Benjamin A. Derman, MD; Andrew M. Davis, MD, MPH

FROM THE MEDICAL LETTER ON DRUGS AND THERAPEUTICS

Pitolisant (Wakix) for Narcolepsy

EDITOR'S NOTE

Reporting Findings From Mediation Analyses

Phil B. Fontanarosa, MD, MBA

MEDICAL NEWS & PERSPECTIVES

Twenty Years After 9/11, Responders Are Still Healing

Jennifer Abbasi

JAMA Medical News Audio: 9/11 Responders’ Health 20 Years Later, Part 1

JAMA Medical News Audio: 9/11 Responders’ Health 20 Years Later, Part 2

NEWS FROM THE FOOD AND DRUG ADMINISTRATION

New Treatment Approved for Adults and Children With Pompe Disease

Bridget M. Kuehn, MS

Lupus Drug Is Approved Despite Previous Clinical Trial Setback

Bridget M. Kuehn, MSJ

“Collaborative Communities” Tackle Device Development Challenges

Bridget M. Kuehn, MSJ

GLOBAL HEALTH

Increase in Myopia Reported Among Children During COVID-19 Lockdown

Bridget M. Kuehn, MSJ

India Takes Aim at Eliminating Visceral Leishmaniasis

Bridget M. Kuehn, MSJ

US Health System Ranks Last Among High-Income Countries

Bridget M. Kuehn, MSJ

POETRY AND MEDICINE

Penned

Rimas Uzgiris, PhD, MFA

JAMA REVISITED

Beethoven’s Deafness

APPENDIX

MD-Granting Medical Schools in the United States, 2020-2021

Barbara Barzansky, PhD; Sylvia I. Etzel

Graduate Medical Education, 2020-2021

Sarah E. Brotherton, PhD; Sylvia I. Etzel

JAMA PATIENT PAGE

Pulmonary Hypertension

Kristin Walter, MD, MS

AUDIO

Audio Editors' Summary

Low Tidal Volume Mechanical Ventilation Using ECCO2R, Probiotics to Prevent VAP in the ICU, TAVR for Bicuspid Aortic Stenosis, Medical Schools in the US, and more

JAMA Medical News Audio

9/11 Responders’ Health 20 Years Later, Part 1

JAMA Medical News Audio

9/11 Responders’ Health 20 Years Later, Part 2

VIDEO

Frequently Asked COVID-19 Vaccine Questions

Immunosuppression, Chronic COVID-19, and SARS-CoV-2 Variants

COMMENT & RESPONSE

Therapeutic Drug Monitoring vs Standard Therapy During Infliximab Induction in Patients With Chronic Immune-Mediated Inflammatory Diseases

Konstantinos Papamichail, MD, PhD; Marla C. Dubinsky, MD; Adam S. Cheifetz, MD

Therapeutic Drug Monitoring vs Standard Therapy During Infliximab Induction in Patients With Chronic Immune-Mediated Inflammatory Diseases

Trond Trætteberg Serkland, MD; Silje Skrede, MD, PhD; Jon Andsnes Berg, MD

Therapeutic Drug Monitoring vs Standard Therapy During Infliximab Induction in Patients With Chronic Immune-Mediated Inflammatory Diseases

Olivier Le Tilly, MS, PharmD; Gilles Paintaud, PhD, MD; David Ternant, PhD, PharmD

Therapeutic Drug Monitoring vs Standard Therapy During Infliximab Induction in Patients With Chronic Immune-Mediated Inflammatory Diseases—Reply

Silje Watterdal Syversen, MD, PhD; Nils Bolstad, MD, PhD; Espen A. Haavardsholm, MD, PhD

Antimicrobial Therapy and Respiratory Hospitalization or Death in Adults With Idiopathic Pulmonary Fibrosis

Ching-Yi Chen, MD; Cheng-Yi Wang, MD; Chih-Cheng Lai, MD

Antimicrobial Therapy and Respiratory Hospitalization or Death in Adults With Idiopathic Pulmonary Fibrosis—Reply

Fernando J. Martinez, MD, MS; Kevin J. Anstrom, PhD; Imre Noth, MD

CORRECTION

Incorrect Group Sizes in Figure

Addition of Nonauthor Collaborator Names of the VICTAS Trial

JAMA MASTHEAD

JAMA

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