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IN THIS ISSUE OF JAMA
Audio Highlights
Audio Editors' Summary: Low Tidal Volume Mechanical Ventilation Using ECCO2R, Probiotics to Prevent VAP in the ICU, TAVR for Bicuspid Aortic Stenosis, Medical Schools in the US, and more
ORIGINAL INVESTIGATION
Caring for the Critically Ill Patient
Effect of Lower Tidal Volume Ventilation Facilitated by Extracorporeal Carbon Dioxide Removal vs Standard Care Ventilation on 90-Day Mortality in Patients With Acute Hypoxemic Respiratory Failure: The REST Randomized Clinical Trial
James J. McNamee, MB, ChB; Michael A. Gillies, MD; Nicholas A. Barrett, MB, ChB; et al.
Effect of Probiotics on Incident Ventilator-Associated Pneumonia in Critically Ill Patients: A Randomized Clinical Trial
Jennie Johnstone, MD, PhD; Maureen Meade, MD, MSc; François Lauzier, MD, MSc; et al.
Earn CME credit
Association Between Transcatheter Aortic Valve Replacement for Bicuspid vs Tricuspid Aortic Stenosis and Mortality or Stroke Among Patients at Low Surgical Risk
Raj R. Makkar, MD; Sung-Han Yoon, MD; Tarun Chakravarty, MD; et al.
Editorial: Transcatheter Valve Replacement for Bicuspid Aortic Stenosis; Catherine M. Otto, MD; David E. Newby, MD
RESEARCH LETTER
Antibody Response After a Third Dose of the mRNA-1273 SARS-CoV-2 Vaccine in Kidney Transplant Recipients With Minimal Serologic Response to 2 Doses
Ilies Benotmane, MD; Gabriela Gautier, MD; Peggy Perrin, MD; et al.
Earn CME credit
Change in Saliva RT-PCR Sensitivity Over the Course of SARS-CoV-2 Infection
Zion Congrave-Wilson, MS; Yesun Lee, PhD; Jaycee Jumarang, MD; et al.
Earn CME credit
SPECIAL COMMUNICATION
A Guideline for Reporting Mediation Analyses of Randomized Trials and Observational Studies: The AGReMA Statement
Hopin Lee, PhD; Aidan G. Cashin, PhD; Sarah E. Lamb, DPhil; et al.
Earn CME credit
Editorial: A Reporting Guideline for Mediation Analyses; Kabir Yadav, MDCM, MS, MSHS; Roger J. Lewis, MD, PhD
Editor’s Note: Reporting Findings From Mediation Analyses; Phil B. Fontanarosa, MD, MBA
VIEWPOINT
Confronting the Delta Variant of SARS-CoV-2, Summer 2021
Carlos del Rio, MD; Preeti N. Malani, MD, MSJ; Saad B. Omer, MBBS, PhD
Earn CME credit
Video: Frequently Asked COVID-19 Vaccine Questions
Video: Immunosuppression, Chronic COVID-19, and SARS-CoV-2 Variants
Potential Implications of SARS-CoV-2 Delta Variant Surges for Rural Areas and Hospitals
Sameer S. Kadri, MD, MS; Steven Q. Simpson, MD
Video: Frequently Asked COVID-19 Vaccine Questions
The Helping to End Addiction Long-term (HEAL) Initiative of the National Institutes of Health
Rebecca G. Baker, PhD; Walter J. Koroshetz, MD; Nora D. Volkow, MD
A PIECE OF MY MIND
It Is What It Is
Meeta Prasad Kerlin, MD, MSCE
EDITORIAL
Transcatheter Valve Replacement for Bicuspid Aortic Stenosis
Catherine M. Otto, MD; David E. Newby, MD
A Reporting Guideline for Mediation Analyses
Kabir Yadav, MDCM, MS, MSHS; Roger J. Lewis, MD, PhD
JAMA CLINICAL GUIDELINES SYNOPSIS
Recommendations for Prevention and Management of Chemotherapy-Induced Peripheral Neuropathy
Benjamin A. Derman, MD; Andrew M. Davis, MD, MPH
FROM THE MEDICAL LETTER ON DRUGS AND THERAPEUTICS
Pitolisant (Wakix) for Narcolepsy
EDITOR'S NOTE
Reporting Findings From Mediation Analyses
Phil B. Fontanarosa, MD, MBA
MEDICAL NEWS & PERSPECTIVES
Twenty Years After 9/11, Responders Are Still Healing
Jennifer Abbasi
JAMA Medical News Audio: 9/11 Responders’ Health 20 Years Later, Part 1
JAMA Medical News Audio: 9/11 Responders’ Health 20 Years Later, Part 2
NEWS FROM THE FOOD AND DRUG ADMINISTRATION
New Treatment Approved for Adults and Children With Pompe Disease
Bridget M. Kuehn, MS
Lupus Drug Is Approved Despite Previous Clinical Trial Setback
Bridget M. Kuehn, MSJ
“Collaborative Communities” Tackle Device Development Challenges
Bridget M. Kuehn, MSJ
GLOBAL HEALTH
Increase in Myopia Reported Among Children During COVID-19 Lockdown
Bridget M. Kuehn, MSJ
India Takes Aim at Eliminating Visceral Leishmaniasis
Bridget M. Kuehn, MSJ
US Health System Ranks Last Among High-Income Countries
Bridget M. Kuehn, MSJ
POETRY AND MEDICINE
Penned
Rimas Uzgiris, PhD, MFA
JAMA REVISITED
Beethoven’s Deafness
APPENDIX
MD-Granting Medical Schools in the United States, 2020-2021
Barbara Barzansky, PhD; Sylvia I. Etzel
Graduate Medical Education, 2020-2021
Sarah E. Brotherton, PhD; Sylvia I. Etzel
JAMA PATIENT PAGE
Pulmonary Hypertension
Kristin Walter, MD, MS
AUDIO
Audio Editors' Summary
Low Tidal Volume Mechanical Ventilation Using ECCO2R, Probiotics to Prevent VAP in the ICU, TAVR for Bicuspid Aortic Stenosis, Medical Schools in the US, and more
JAMA Medical News Audio
9/11 Responders’ Health 20 Years Later, Part 1
JAMA Medical News Audio
9/11 Responders’ Health 20 Years Later, Part 2
VIDEO
Frequently Asked COVID-19 Vaccine Questions
Immunosuppression, Chronic COVID-19, and SARS-CoV-2 Variants
COMMENT & RESPONSE
Therapeutic Drug Monitoring vs Standard Therapy During Infliximab Induction in Patients With Chronic Immune-Mediated Inflammatory Diseases
Konstantinos Papamichail, MD, PhD; Marla C. Dubinsky, MD; Adam S. Cheifetz, MD
Therapeutic Drug Monitoring vs Standard Therapy During Infliximab Induction in Patients With Chronic Immune-Mediated Inflammatory Diseases
Trond Trætteberg Serkland, MD; Silje Skrede, MD, PhD; Jon Andsnes Berg, MD
Therapeutic Drug Monitoring vs Standard Therapy During Infliximab Induction in Patients With Chronic Immune-Mediated Inflammatory Diseases
Olivier Le Tilly, MS, PharmD; Gilles Paintaud, PhD, MD; David Ternant, PhD, PharmD
Therapeutic Drug Monitoring vs Standard Therapy During Infliximab Induction in Patients With Chronic Immune-Mediated Inflammatory Diseases—Reply
Silje Watterdal Syversen, MD, PhD; Nils Bolstad, MD, PhD; Espen A. Haavardsholm, MD, PhD
Antimicrobial Therapy and Respiratory Hospitalization or Death in Adults With Idiopathic Pulmonary Fibrosis
Ching-Yi Chen, MD; Cheng-Yi Wang, MD; Chih-Cheng Lai, MD
Antimicrobial Therapy and Respiratory Hospitalization or Death in Adults With Idiopathic Pulmonary Fibrosis—Reply
Fernando J. Martinez, MD, MS; Kevin J. Anstrom, PhD; Imre Noth, MD
CORRECTION
Incorrect Group Sizes in Figure
Addition of Nonauthor Collaborator Names of the VICTAS Trial
JAMA MASTHEAD
JAMA
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