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IN THIS ISSUE OF JAMA
Audio Highlights
Audio Editors' Summary: Hypertonic Saline for TBI, Alpha-Blockers vs Stimulants for Preschool Children With ADHD, Maternal SARS-CoV-2 and Neonatal Outcomes, and more
ORIGINAL INVESTIGATION
Effect of Continuous Infusion of Hypertonic Saline vs Standard Care on 6-Month Neurological Outcomes in Patients With Traumatic Brain Injury: The COBI Randomized Clinical Trial
Antoine Roquilly, MD, PhD; Jean Denis Moyer, MD; Olivier Huet, MD, PhD; et al.
Earn CME credit
α2-Adrenergic Agonists or Stimulants for Preschool-Age Children With Attention-Deficit/Hyperactivity Disorder
Elizabeth Harstad, MD, MPH; Justine Shults, PhD; William Barbaresi, MD; et al.
Editorial: Comparison of Medication Treatments for Preschool Children With ADHD: A First Step Toward Addressing a Critical Gap; Tanya E. Froehlich, MD, MS
Association of Maternal SARS-CoV-2 Infection in Pregnancy With Neonatal Outcomes
Mikael Norman, MD; Lars Navér, MD; Jonas Söderling, PhD; et al.
Earn CME credit
Editorial: Understanding Risk for Newborns Born to SARS-CoV-2–Positive Mothers; Dani Dumitriu, MD, PhD; Cynthia Gyamfi-Bannerman, MD, MS
RESEARCH LETTER
S-Gene Target Failure as a Marker of Variant B.1.1.7 Among SARS-CoV-2 Isolates in the Greater Toronto Area, December 2020 to March 2021
Kevin A. Brown, PhD; Jonathan Gubbay, MBBS, MMedSc; Jessica Hopkins, MD, MHSc; et al.
Earn CME credit
Preliminary Investigation of In situ Thrombus Within Patent Foramen Ovale in Patients With and Without Stroke
Chaowu Yan, PhD, MD; Hua Li, MD
US PREVENTIVE SERVICES TASK FORCE
Recommendation Statement
Behavioral Counseling Interventions for Healthy Weight and Weight Gain in Pregnancy: US Preventive Services Task Force Recommendation Statement
US Preventive Services Task Force
Earn CME credit
Editorial: Behavioral Counseling Interventions for Healthy Weight During Pregnancy: An Ambitious Endeavor; D. Yvette LaCoursiere, MD, MPH
JAMA Patient Page: Behavioral Interventions for Healthy Weight Gain During Pregnancy; Jill Jin, MD, MPH
Audio Clinical Review: USPSTF Recommendation: Behavioral Counseling Interventions for Healthy Weight and Weight Gain in Pregnancy
Evidence Report
Counseling and Behavioral Interventions for Healthy Weight and Weight Gain in Pregnancy: Evidence Report and Systematic Review for the US Preventive Services Task Force
Amy G. Cantor, MD, MPH; Rebecca M. Jungbauer, DrPH, MPH, MA; Marian McDonagh, PharmD; et al.
VIEWPOINT
Precision Medicine for COVID-19: Phenotype Anarchy or Promise Realized?
Kimberley DeMerle, MD, MSc; Derek C. Angus, MD, MPH; Christopher W. Seymour, MD, MSc
Earn CME credit
Designing a Successful Primary Care Physician Capitation Model
Ezekiel J. Emanuel, MD, PhD; Farzad Mostashari, MD, ScM; Amol S. Navathe, MD, PhD
High and Rising Working-Age Mortality in the US: A Report From the National Academies of Sciences, Engineering, and Medicine
Kathleen Mullan Harris, PhD; Steven H. Woolf, MD, MPH; Darrell J. Gaskin, PhD
A PIECE OF MY MIND
Defense Against Numbness
Cynthia X. He, MD, PhD
EDITORIAL
Comparison of Medication Treatments for Preschool Children With ADHD: A First Step Toward Addressing a Critical Gap
Tanya E. Froehlich, MD, MS
Understanding Risk for Newborns Born to SARS-CoV-2–Positive Mothers
Dani Dumitriu, MD, PhD; Cynthia Gyamfi-Bannerman, MD, MS
Earn CME credit
Behavioral Counseling Interventions for Healthy Weight During Pregnancy: An Ambitious Endeavor
D. Yvette LaCoursiere, MD, MPH
JAMA GUIDE TO STATISTICS AND METHODS
Adjusting for Nonadherence or Stopping Treatments in Randomized Clinical Trials
Amanda I. Adler, MD, PhD; Nicholas R. Latimer, MSc, PhD
JAMA INSIGHTS
Indoor Air Changes and Potential Implications for SARS-CoV-2 Transmission
Joseph G. Allen, DSc, MPH; Andrew M. Ibrahim, MD, MSc
Earn CME credit
MEDICAL NEWS & PERSPECTIVES
Researchers Tie Severe Immunosuppression to Chronic COVID-19 and Virus Variants
Jennifer Abbasi
Earn CME credit
JAMA Medical News Audio: May 2021 Medical News Summary
An Inside Look at a Post–COVID-19 Clinic
Kristin Walter, MD, MS
Earn CME credit
JAMA Medical News Audio: An Inside Look at a Post–COVID-19 Clinic
NEWS FROM THE CENTERS FOR DISEASE CONTROL AND PREVENTION
Massive Costs of the US Opioid Epidemic in Lives and Dollars
Bridget M. Kuehn, MSJ
Sexually Transmitted Disease Cases Continue to Break Records
Bridget M. Kuehn, MSJ
CLINICAL TRIALS UPDATE
Clear Surgical Masks Create More Positive Interactions With Patients
Anita Slomski
Upadacitinib Noninferior to Adalimumab for Psoriatic Arthritis
Anita Slomski
Patients Favor Surgical Repair of Ruptured ACL
Anita Slomski
Shorter Antibiotic Therapy Safe for Inpatients With Pneumonia
Anita Slomski
Patient Navigation Reduces Substance Abuse Disorder Readmissions
Anita Slomski
HEALTH AGENCIES UPDATE
Allergic Reactions to mRNA Vaccines
Rita Rubin, MA
Improving Maternal Health
Rita Rubin, MA
Free, At-Home Rapid SARS-CoV-2 Tests
Rita Rubin, MA
POETRY AND MEDICINE
Oxheart
Katie Lehman, MFA
JAMA REVISITED
The Social Responsibilities of Modern Medicine
JAMA PATIENT PAGE
Behavioral Interventions for Healthy Weight Gain During Pregnancy
Jill Jin, MD, MPH
Audio Clinical Review: USPSTF Recommendation: Behavioral Counseling Interventions for Healthy Weight and Weight Gain in Pregnancy
AUDIO
Audio Editors' Summary
Hypertonic Saline for TBI, Alpha-Blockers vs Stimulants for Preschool Children With ADHD, Maternal SARS-CoV-2 and Neonatal Outcomes, and more
Audio Clinical Review
USPSTF Recommendation: Behavioral Counseling Interventions for Healthy Weight and Weight Gain in Pregnancy
JAMA Medical News Audio
May 2021 Medical News Summary
JAMA Medical News Audio
An Inside Look at a Post–COVID-19 Clinic
COMMENT & RESPONSE
Effect of Sodium Nitrite on Survival of Cardiac Arrest to Hospital Admission
Wentao Sang, MS; Feng Xu, MD
Effect of Sodium Nitrite on Survival of Cardiac Arrest to Hospital Admission—Reply
Francis Kim, MD; Charles Maynard, PhD; Graham Nichol, MD, MPH
US Hospital Data About Neonatal Abstinence Syndrome and Maternal Opioid-Related Diagnoses
Marjorie Meyer, MD; Jerilyn Metayer, RN
US Hospital Data About Neonatal Abstinence Syndrome and Maternal Opioid-Related Diagnoses—Reply
Ashley H. Hirai, PhD; Jean Y. Ko, PhD; Stephen W. Patrick, MD, MPH, MS
CORRECTION
Addition of Nonauthor Collaborator Names of the COVID-19 Lombardy ICU Network
JAMA MASTHEAD
JAMA
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