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IN THIS ISSUE OF JAMA
Audio Highlights
Audio Editors' Summary: Canakinumab for Severe COVID-19, Medical Debt in the US, Novel Lipid-Lowering Therapies, and more
ORIGINAL INVESTIGATION
Effect of Canakinumab vs Placebo on Survival Without Invasive Mechanical Ventilation in Patients Hospitalized With Severe COVID-19: A Randomized Clinical Trial
Roberto Caricchio, MD; Antonio Abbate, MD, PhD; Ivan Gordeev, PhD; et al.
Earn CME credit
Effect of Oral Ranitidine on Urinary Excretion of N-Nitrosodimethylamine (NDMA): A Randomized Clinical Trial
Jeffry Florian, PhD; Murali K. Matta, PhD; Ryan DePalma, PhD; et al.
Editorial: Ranitidine and Risk of N-Nitrosodimethylamine (NDMA) Formation; C. Michael White, PharmD; Adrian V. Hernandez, MD, PhD
Medical Debt in the US, 2009-2020
Raymond Kluender, PhD; Neale Mahoney, PhD; Francis Wong, PhD; et al.
Earn CME credit
Editorial: Medical Debt as a Social Determinant of Health; Carlos F. Mendes de Leon, PhD; Jennifer J. Griggs, MD, MPH
RESEARCH LETTER
Sperm Parameters Before and After COVID-19 mRNA Vaccination
Daniel C. Gonzalez, BS; Daniel E. Nassau, MD; Kajal Khodamoradi, PhD; et al.
Earn CME credit
Prescription Drug Monitoring Program Mandates and Opioids Dispensed Following Emergency Department Encounters for Patients With Sickle Cell Disease or Cancer With Bone Metastasis
Hao Zhang, PhD; Austin S. Kilaru, MD, MSHP; Zachary F. Meisel, MD, MPH, MSHP; et al.
SPECIAL COMMUNICATION
Guidelines for Reporting Trial Protocols and Completed Trials Modified Due to the COVID-19 Pandemic and Other Extenuating Circumstances: The CONSERVE 2021 Statement
Aaron M. Orkin, MD, MSc, MPH; Peter J. Gill, MD, DPhil; Davina Ghersi, MD, PhD; et al.
VIEWPOINT
Intensive Medical Management to Prevent Large and Small Artery Atherothrombotic Stroke: Time to Expand the Horizon
Meng Lee, MD; Bruce Ovbiagele, MD, MSc, MAS, MBA; Jeffrey L. Saver, MD
Sharing Technology and Vaccine Doses to Address Global Vaccine Inequity and End the COVID-19 Pandemic
Matthew M. Kavanagh, PhD; Lawrence O. Gostin, JD; Madhavi Sunder, JD
Ethical Considerations of Offering Benefits to COVID-19 Vaccine Recipients
Govind Persad, JD, PhD; Ezekiel J. Emanuel, MD, PhD
A PIECE OF MY MIND
To Err Is Human, to Apologize Is Hard
Thalia Margalit Krakower, MD
EDITORIAL
Ranitidine and Risk of N-Nitrosodimethylamine (NDMA) Formation
C. Michael White, PharmD; Adrian V. Hernandez, MD, PhD
Medical Debt as a Social Determinant of Health
Carlos F. Mendes de Leon, PhD; Jennifer J. Griggs, MD, MPH
JAMA INSIGHTS
Clinical Update
Novel Lipid-Lowering Therapies to Reduce Cardiovascular Risk
John T. Wilkins, MD, MS; Donald M. Lloyd-Jones, MD, ScM
Audio Clinical Review: Novel Lipid-Lowering Therapies to Reduce Cardiovascular Risk
Genomics and Precision Health
Challenges of Accuracy in Germline Clinical Sequencing Data
Ryan Poplin, MS; Justin M. Zook, PhD; Mark DePristo, PhD
FROM THE MEDICAL LETTER ON DRUGS AND THERAPEUTICS
Metoclopramide Nasal Spray (Gimoti) for Diabetic Gastroparesis
MEDICAL NEWS & PERSPECTIVES
Alcohol-Related Diseases Increased as Some People Drank More During the COVID-19 Pandemic
Rita Rubin, MA
Another COVID-19 Fallout: Teens’ Happy Hour With Parents
Anita Slomski, MA
NEWS FROM THE FOOD AND DRUG ADMINISTRATION
FDA: Stop Using Medtronic’s Heartware Ventricular Assist Device
Bridget M. Kuehn, MSJ
New Software Can Aid in Early Autism Spectrum Disorder Diagnosis
Bridget M. Kuehn, MSJ
Treatment Approved for “Undruggable” Lung Cancer
Bridget M. Kuehn, MSJ
GLOBAL HEALTH
Antibiotic Use in UK’s COVID-19 Patients Often Unnecessary
Bridget M. Kuehn, MSJ
Urgent Need to Reduce Heart Disease Among Women Worldwide
Bridget M. Kuehn, MSJ
Patients in Afghanistan Face Growing Obstacles to Care
Bridget M. Kuehn, MSJ
POETRY AND MEDICINE
Javits Center
JoAnne Burger, MD
JAMA REVISITED
Current Comment
JAMA PATIENT PAGE
Low Back Pain
Adrian C. Traeger, PhD; Amir Qaseem, MD, PhD, MHA; James H. McAuley, PhD
AUDIO
Audio Editors' Summary
Canakinumab for Severe COVID-19, Medical Debt in the US, Novel Lipid-Lowering Therapies, and more
Audio Clinical Review
Novel Lipid-Lowering Therapies to Reduce Cardiovascular Risk
COMMENT & RESPONSE
Backstop Price Caps in Commercial Health Care Markets
Jay B. Lusk, BSc; Ryan C. McDevitt, PhD
Backstop Price Caps in Commercial Health Care Markets—Reply
Michael E. Chernew, PhD; Maximilian J. Pany, BA
Strategies to Overcome the Market Dominance of Hospitals
Benjamin S. Kornitzer, MD
Strategies to Overcome the Market Dominance of Hospitals—Reply
Soleil Shah, MSc; Amol S. Navathe, MD, PhD; Robert P. Kocher, MD
CORRECTION
Addition of Nonauthor Collaborator Names of the WHIST Trial
Incorrect Terminology
Incorrect Labels in Figure
JAMA MASTHEAD
JAMA
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