IN THIS ISSUE OF JAMA
Audio Highlights
Audio Editors' Summary: Emergency Care Bundle for Heart Failure, AI Detection of Cancer Genes, Bladder Cancer Review, and more
ORIGINAL INVESTIGATION
Effect of an Emergency Department Care Bundle on 30-Day Hospital Discharge and Survival Among Elderly Patients With Acute Heart Failure: The ELISABETH Randomized Clinical Trial
Yonathan Freund, MD, PhD; Marine Cachanado, MSc; Quentin Delannoy, MD; et al.
Earn CME credit
Detection of Pathogenic Variants With Germline Genetic Testing Using Deep Learning vs Standard Methods in Patients With Prostate Cancer and Melanoma
Saud H. AlDubayan, MD; Jake R. Conway, BSc; Sabrina Y. Camp, BSc; et al.
Earn CME credit
Editorial: Bioinformatics, Sequencing Accuracy, and the Credibility of Clinical Genomics; W. Gregory Feero, MD, PhD
Association of Childhood Lead Exposure With MRI Measurements of Structural Brain Integrity in Midlife
Aaron Reuben, MEM; Maxwell L. Elliott, MA; Wickliffe C. Abraham, PhD; et al.
RESEARCH LETTER
Financial Penalties Imposed on Large Pharmaceutical Firms for Illegal Activities
Denis G. Arnold, PhD; Oscar Jerome Stewart, PhD; Tammy Beck, PhD
VIEWPOINT
Preventing the Spread of SARS-CoV-2 With Masks and Other “Low-tech” Interventions
Andrea M. Lerner, MD, MS; Gregory K. Folkers, MS, MPH; Anthony S. Fauci, MD
Earn CME credit
Conversations with Dr Bauchner: Coronavirus Update With Rochelle Walensky, MD, MPH
Postapproval Vaccine Safety Surveillance for COVID-19 Vaccines in the US
Grace M. Lee, MD, MPH; José R. Romero, MD; Beth P. Bell, MD, MPH
Earn CME credit
Postlicensure Evaluation of COVID-19 Vaccines
Manish M. Patel, MD; Michael L. Jackson, PhD; Jill Ferdinands, PhD
Earn CME credit
Heritable Human Genome Editing: The International Commission Report
Eli Y. Adashi, MD, MS; I. Glenn Cohen, JD
Conversations with Dr Bauchner: Heritable Human Genome Editing (HHGE)—The International Commission Report
A PIECE OF MY MIND
Shear Forces
Stephanie Parks Taylor, MD, MS
Earn CME credit
EDITORIAL
Bioinformatics, Sequencing Accuracy, and the Credibility of Clinical Genomics
W. Gregory Feero, MD, PhD
REVIEW
Bladder Cancer: A Review
Andrew T. Lenis, MD, MS; Patrick M. Lec, MD; Karim Chamie; et al.
Earn CME credit
Audio Clinical Review: Hematuria and Bladder Cancer
JAMA CLINICAL CHALLENGE
Dyschromic Nails, Exertional Dyspnea, and Lower Extremity Edema
Soumya Chatterjee, MD, MS; Elliott Chandler Dasenbrook, MD, MHS
Earn CME credit
MEDICAL NEWS & PERSPECTIVES
Nursing Homes’ Next Test—Vaccinating Workers Against COVID-19
Mary Chris Jaklevic, MSJ
Earn CME credit
NEWS FROM THE FOOD AND DRUG ADMINISTRATION
Breast Implant Manufacturers Get Labeling Guidance
Mary Chris Jaklevic, MSJ
FDA Expands Food Safety Collaboration With Mexico
Mary Chris Jaklevic, MSJ
Warning Concerns Respirator Decontamination System
Mary Chris Jaklevic, MSJ
THE JAMA FORUM
To Truly Build the Affordable Care Act Into Universal Coverage, More Creativity Is Needed
Paul Shafer, PhD; Austin B. Frakt, PhD
GLOBAL HEALTH
Dried Blood Spots May Offer Route to Wider Antibody Testing
Bridget M. Kuehn, MSJ
Partnership to Make 120 Million COVID-19 Rapid Tests Available
Bridget M. Kuehn, MSJ
Global Mental Health Services Are Collapsing as Demand Grows
Bridget M. Kuehn, MSJ
POETRY AND MEDICINE
Voyager
Fiona Miller
JAMA REVISITED
State Medicine vs Fads: By Granville P. Conn, A.M., M.D., Concord, N. H.
JAMA PATIENT PAGE
Bladder Cancer
Andrew T. Lenis, MD, MS; Patrick M. Lec, MD; Karim Chamie, MD, MSHS
Audio Clinical Review: Hematuria and Bladder Cancer
AUDIO
Audio Editors' Summary
Emergency Care Bundle for Heart Failure, AI Detection of Cancer Genes, Bladder Cancer Review, and more
Conversations with Dr Bauchner
Heritable Human Genome Editing (HHGE)—The International Commission Report
Audio Clinical Review
Hematuria and Bladder Cancer
COMMENT & RESPONSE
Assessing Alternative Payment Models
Suhas Gondi, BA; Rishi K. Wadhera, MD, MPP, MPhil
Assessing Alternative Payment Models—Reply
Amol S. Navathe, MD, PhD; Connor W. Boyle, BA; Ezekiel J. Emanuel, MD, PhD
Testing Clinical Prediction Models
Benjamin A. Goldstein, PhD; Michael J. Pencina, PhD
Testing Clinical Prediction Models
Junfeng Wang, PhD; Yue Li, MSc
Testing Clinical Prediction Models—Reply
Amin Adibi, MSc; Mohsen Sadatsafavi, MD, PhD; John P. A. Ioannidis, MD, DSc
JAMA MASTHEAD
JAMA
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