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IN THIS ISSUE OF JAMA
Audio Highlights
Audio: Bacterial Consortium Therapy for Prevention of Recurrent C diff Infection, 4-Factor Prothrombin Complex Concentrate in Patients With Trauma, Review of Pituitary Adenomas, and more
ORIGINAL INVESTIGATION
Caring for the Critically Ill Patient
Efficacy and Safety of Early Administration of 4-Factor Prothrombin Complex Concentrate in Patients With Trauma at Risk of Massive Transfusion: The PROCOAG Randomized Clinical Trial
Pierre Bouzat, MD, PhD; Jonathan Charbit, MD; Paer-Selim Abback, MD; et al.
Emulation of Randomized Clinical Trials With Nonrandomized Database Analyses: Results of 32 Clinical Trials
Shirley V. Wang, PhD, ScM; Sebastian Schneeweiss, MD, ScD; RCT-DUPLICATE Initiative
Editorial: Randomized Trials vs Real-world Evidence: How Can Both Inform Decision-making?; R. Christopher Sheldrick, PhD
PRELIMINARY COMMUNICATION
VE303, a Defined Bacterial Consortium, for Prevention of Recurrent Clostridioides difficile Infection: A Randomized Clinical Trial
Thomas Louie, MD; Yoav Golan, MD; Sahil Khanna, MBBS, MS; et al.
RESEARCH LETTER
Quantity of Melatonin and CBD in Melatonin Gummies Sold in the US
Pieter A. Cohen, MD; Bharathi Avula, PhD; Yan-Hong Wang, PhD; et al.
Trends in Buprenorphine Initiation and Retention in the United States, 2016-2022
Kao-Ping Chua, MD, PhD; Thuy D. Nguyen, PhD; Jason Zhang, BS; et al.
Comparison of Availability of Trial Results in ClinicalTrials.gov and PubMed by Data Source and Funder Type
Julianne T. Nelson, PhD, MPH; Tony Tse, PhD; Yvonne Puplampu-Dove, PhD; et al.
VIEWPOINT
Medical School Rankings—Bad for the Health of the Profession and the Public
Holly J. Humphrey, MD; Dana Levinson, MPH; Keme Carter, MD
Audio: Medical Education: Is Medical School Ranking the Best Assessment of Quality?
Does Insulin Price Reduction Suggest a Path Forward for Lowering Drug Costs?
Troyen Brennan, MD, JD
Harnessing the Promise of Artificial Intelligence Responsibly
David A. Dorr, MD, MS; Laura Adams, MS; Peter Embí, MD, MS
AI-Generated Medical Advice—GPT and Beyond
Claudia E. Haupt, JSD, PhD; Mason Marks, MD, JD
A PIECE OF MY MIND
Made With Love in a Petri Dish
Lauren Rissman, MD
EDITORIAL
Randomized Trials vs Real-world Evidence: How Can Both Inform Decision-making?
R. Christopher Sheldrick, PhD
Looking Back and Moving Forward—JAMA 2022 Year in Review
Kirsten Bibbins-Domingo, PhD, MD, MAS; Annette Flanagin, MA, RN; Stacy L. Christiansen, MA; et al.
Audio Author Interview: A Conversation With Dr Kirsten Bibbins-Domingo, JAMA’s New Editor in Chief
REVIEW
Diagnosis and Management of Pituitary Adenomas: A Review
Nicholas A. Tritos, MD, DSc; Karen K. Miller, MD
Earn CME credit
JAMA INSIGHTS
Women's Health
Management of Early Pregnancy Loss
Sara Neill, MD, MPH
Earn CME credit
EDITOR'S NOTE
From “Things End” to Elegy: The Difference Diction Makes
Rafael Campo, MA, MD
MEDICAL NEWS & PERSPECTIVES
It Takes an Average of 17 Years for Evidence to Change Practice—the Burgeoning Field of Implementation Science Seeks to Speed Things Up
Rita Rubin, MA
All 3 Major Insulin Manufacturers Are Cutting Their Prices—Here’s What the News Means for Patients With Diabetes
Melissa Suran, PhD, MSJ
MEDICAL NEWS IN BRIEF
WHO Warns “Very High” Global Risk as Cholera Cases Spread
Emily Harris
Meta-analysis: Analgesics’ Value for Lower Back Pain Uncertain
Emily Harris
Updates on the Way for US Organ Transplant System
Emily Harris
Including Medicare Advantage Beneficiaries Changes Hospital Rankings
Emily Harris
Study: US COVID-19 Outcomes Tied to State Characteristics and Policies
Emily Harris
Pembrolizumab Immunotherapy Improved Endometrial Cancer Survival
Emily Harris
WHO: Concerning Spread of Dengue, Chikungunya in Latin America
Emily Harris
Multiple Studies Link Unexplained Pediatric Hepatitis to AAV2
Emily Harris
FDA Green-lights First Over-the-counter Naloxone Spray
Emily Harris
POETRY AND MEDICINE
Resuscitation Bay Elegy
Jorden M. Klein, MD
Editor's Note: From “Things End” to Elegy: The Difference Diction Makes; Rafael Campo, MA, MD
JAMA REVISITED
The Present Status of Viruses and Virus Diseases: Edwin W. Schultz, M.D., Stanford University, Calif.
PEER REVIEWERS LIST
JAMA Peer Reviewers in 2022
Editorial: Looking Back and Moving Forward—JAMA 2022 Year in Review; Kirsten Bibbins-Domingo, PhD, MD, MAS; Annette Flanagin, MA, RN; Stacy L. Christiansen, MA; Greg Curfman, MD
JAMA PATIENT PAGE
Early Pregnancy Loss
Kristin Walter, MD, MS
AUDIO
Editor’s Summary Audio
Bacterial Consortium Therapy for Prevention of Recurrent C diff Infection, 4-Factor Prothrombin Complex Concentrate in Patients With Trauma, Review of Pituitary Adenomas, and more
Audio Author Interview
Medical Education: Is Medical School Ranking the Best Assessment of Quality?
Audio Author Interview
A Conversation With Dr Kirsten Bibbins-Domingo, JAMA’s New Editor in Chief
COMMENT & RESPONSE
Review of Progress and Challenges in Bacterial Meningitis
Yannis Ait-Ali, MD; Léo Bourlon, MD; Frédéric M. Jacobs, MD, MSc
Review of Progress and Challenges in Bacterial Meningitis
Simone Giuliano, MD; Francesco Sbrana, MD; Carlo Tascini, MD
Review of Progress and Challenges in Bacterial Meningitis—Reply
Rodrigo Hasbun, MD, MPH
Biopsychosocial Intervention or Postural Therapy in Patients With Spine Pain
Zhaochen Zhu, MSc; Alessandro Chiarotto, PhD; Bart W. Koes, PhD
Biopsychosocial Intervention or Postural Therapy in Patients With Spine Pain—Reply
Eugene Hsu, MD, MBA; Arnold Milstein, MD, MPH; Niteesh Choudhry, MD, PhD
JAMA MASTHEAD
JAMA
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