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Top Clinical Challenges of 2022

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A Patient With Jaundice and Malaise
  1. Check plasma HIV-1 RNA level
  2. Order testing for hepatitis E virus IgM antibody
  3. Order testing for anti–smooth muscle antibody
  4. Order testing for hepatitis delta virus (HDV) IgM and IgG antibodies and, if positive, test for HDV RNA
What Would You Do Next?


Fever, Hypotension, and a Worsening Necrotic WoundDanielle M. Peterson, MD; William E. Damsky, MD, PhD; Matthew D. Vesely, MD, PhD

1 Credit CME   |    April 19, 2022

Joint Pain in a Woman Wearing a Face MaskJason E. Liebowitz, MD; Maximilian F. Konig, MD

1 Credit CME   |    April 12, 2022

Urticaria 12 Days After COVID-19 mRNA Booster VaccinationAnna R. Wolfson, MD; Esther E. Freeman, MD, PhD; Kimberly G. Blumenthal, MD, MSc

1 Credit CME   |    May 3, 2022

An 18-Year-Old Woman With Recurrent Skin, Nail, and Oral Mucosal AbnormalitiesZhaoyuan Wang, MD, PhD; Xiaoyong Man, MD, PhD

1 Credit CME   |    September 20, 2022

Ulcerated Plaques on the Scalp and Dorsal Hands of an Older ManAmrita Goyal, MD; Daniel O’Leary, MD; Misha Rosenbach, MD

1 Credit CME   |    May 17, 2022

Chronic Abdominal Pain and Anemia in a 59-Year-Old ManTakashi Oshima, MD; Kiyoshi Kinjo, MD, MS; Mitsuyo Kinjo, MD, MPH

1 Credit CME   |    July 12, 2022

Recurrent Eye and Ear Pain in an Older PatientMonica Yang, MD; Mary Margaretten, MD, MAS

1 Credit CME   |    June 21, 2022


Diagnosis and Treatment of Sexually Transmitted InfectionsSusan Tuddenham, MD, MPH; Matthew M. Hamill, MBChB, PhD; Khalil G. Ghanem, MD, PhD

1 Credit CME   |    January 11, 2022

Prevalence and Cumulative Risk of Familial Idiopathic Dilated CardiomyopathyGordon S. Huggins, MD; Daniel D. Kinnamon, PhD; Garrie J. Haas, MD; et al

1 Credit CME   |    February 1, 2022

Effect of a Community-Based Medical Oncology Depression Screening Program With Behavioral Health Referrals Among Patients With Breast CancerErin E. Hahn, PhD, MPH; Corrine E. Munoz-Plaza, MPH; Dana Pounds, MS; et al

1 Credit CME   |    January 4, 2022

Effect of Subcutaneous Tirzepatide vs Placebo Added to Titrated Insulin Glargine on Glycemic Control in Patients With Type 2 DiabetesDominik Dahl, MD; Yukiko Onishi, MD, PhD; Paul Norwood, MD; et al

1 Credit CME   |    February 8, 2022

Diagnosis and Management of Lumbar Spinal StenosisJeffrey N. Katz, MD, MSc; Zoe E. Zimmerman, BS; Hanna Mass, BA; et al

1 Credit CME   |    May 3, 2022

Update on the Monkeypox OutbreakCarlos del Rio, MD; Preeti N. Malani, MD, MSJ

1 Credit CME   |    September 13, 2022

Browse All JAMA CME >>


Earn AMA PRA Category 1 Credit™ and get Maintenance of Certification credit when you complete any JAMA Network journal article CME activity. Physicians licensed in California, Maryland, Oregon, North Dakota, North Carolina, Tennessee, and Maine get CME automatically transferred to their state boards. CME activities are free for AMA members and journal subscribers. Learn more.

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