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IN THIS ISSUE OF JAMA
Audio Highlights
Audio Editors' Summary: Dexamethasone Dose in Adults With Severe COVID-19, Mental Stress-Induced Myocardial Ischemia and Cardiovascular Events, Medicare Outcomes From the Oncology Care Model, and more
ORIGINAL INVESTIGATION
Caring for the Critically Ill Patient
Effect of 12 mg vs 6 mg of Dexamethasone on the Number of Days Alive Without Life Support in Adults With COVID-19 and Severe Hypoxemia: The COVID STEROID 2 Randomized Trial
The COVID STEROID 2 Trial Group
Editorial: Glucocorticoid Dose in COVID-19: Lessons for Clinical Trials During a Pandemic; Steven A. Webb, MD, PhD; Alisa M. Higgins, PhD; Colin J. McArthur, MBChB
Video: Effect of 12 mg vs 6 mg of Dexamethasone on the Number of Days Alive Without Life Support in Adults With COVID-19 and Severe Hypoxemia
Association of Mental Stress–Induced Myocardial Ischemia With Cardiovascular Events in Patients With Coronary Heart Disease
Viola Vaccarino, MD, PhD; Zakaria Almuwaqqat, MD; Jeong Hwan Kim, MD; et al.
Earn CME credit
Editorial: Mental Stress–Induced Myocardial Ischemia: When the Mind Controls the Fate of the Heart; Paco E. Bravo, MD; Thomas P. Cappola, MD, ScM
Association of Participation in the Oncology Care Model With Medicare Payments, Utilization, Care Delivery, and Quality Outcomes
Nancy L. Keating, MD, MPH; Shalini Jhatakia, MA; Gabriel A. Brooks, MD, MPH; et al.
Earn CME credit
Editorial: Medicare Spending, Utilization, and Quality in the Oncology Care Model; Raymond U. Osarogiagbon, MBBS; Samyukta Mullangi, MD; Deborah Schrag, MD, MPH
RESEARCH LETTER
Characteristics and Outcomes of Products Seeking Competitive Generic Therapy Designation and Exclusivity
Harinder Singh Chahal, PharmD, MSc; Annabelle C. Fowler, PhD; Rinku Patel, PharmD; et al.
COVID-19 Incidence and Mortality in Federal and State Prisons Compared With the US Population, April 5, 2020, to April 3, 2021
Neal Marquez, MPH; Julie A. Ward, MN, RN; Kalind Parish, MA; et al.
Medical Specialty Board Parental, Caregiver, and Medical Leave Policy Updates After 2021 American Board of Medical Specialties Mandate
Kirti Magudia, MD, PhD; Shauna R. Campbell, DO; Erika L. Rangel, MD, MS; et al.
VIEWPOINT
A Policy Prescription for Reducing Health Disparities—Achieving Pharmacoequity
Utibe R. Essien, MD, MPH; Stacie B. Dusetzina, PhD; Walid F. Gellad, MD, MPH
Audio Author Interview: A Continued Focus on Equity Through Pharmacoequity and Digital Health Equity: Two Current Viewpoints
Focusing on Digital Health Equity
Courtney R. Lyles, PhD; Robert M. Wachter, MD; Urmimala Sarkar, MD, MPH
Audio Author Interview: A Continued Focus on Equity Through Pharmacoequity and Digital Health Equity: Two Current Viewpoints
The Affordable Care Act Resurrected: Curtailing the Ranks of the Uninsured
Eli Y. Adashi, MD, MS; Daniel P. O’Mahony, MSLS; I. Glenn Cohen, JD
A PIECE OF MY MIND
Little Acts and Big Differences: Perspectives on Civility in Medicine
Danielle Dougherty, MD; Erin E. Perrone, MD
EDITORIAL
Glucocorticoid Dose in COVID-19: Lessons for Clinical Trials During a Pandemic
Steven A. Webb, MD, PhD; Alisa M. Higgins, PhD; Colin J. McArthur, MBChB
Video: Effect of 12 mg vs 6 mg of Dexamethasone on the Number of Days Alive Without Life Support in Adults With COVID-19 and Severe Hypoxemia
Mental Stress–Induced Myocardial Ischemia: When the Mind Controls the Fate of the Heart
Paco E. Bravo, MD; Thomas P. Cappola, MD, ScM
Medicare Spending, Utilization, and Quality in the Oncology Care Model
Raymond U. Osarogiagbon, MBBS; Samyukta Mullangi, MD; Deborah Schrag, MD, MPH
REVIEW
Cardiogenic Shock After Acute Myocardial Infarction: A Review
Marc D. Samsky, MD; David A. Morrow, MD, MPH; Alastair G. Proudfoot, MBChB, PhD; et al.
Earn CME credit
JAMA CLINICAL CHALLENGE
Blue Pigmentation of the Skin, Sclera, and Teeth
Nina A. Ran, MD; Matthew L. Hedberg, MD, PhD; Misha Rosenbach, MD
Earn CME credit
FROM THE MEDICAL LETTER ON DRUGS AND THERAPEUTICS
Higher-Dose Naloxone Nasal Spray (Kloxxado) for Opioid Overdose
MEDICAL NEWS & PERSPECTIVES
The Flawed Science of Antibody Testing for SARS-CoV-2 Immunity
Jennifer Abbasi
Quick Uptakes
Survey Describes How Patients With Arthritis Get Moving
Rebecca Voelker, MSJ
NEWS FROM THE CENTERS FOR DISEASE CONTROL AND PREVENTION
Targeted Efforts Needed to Curb Arthritis-Related Disability
Bridget M. Kuehn, MSJ
Low PrEP Awareness, Referrals for Black, Hispanic, and Latino People
Bridget M. Kuehn, MSJ
BIOTECH INNOVATIONS
Pfizer Launches Phase 1 mRNA Flu Vaccine Trial
Jennifer Abbasi
Flu Vaccine Candidate Elicits Enhanced Immune Response
Jennifer Abbasi
“Polymutant” Spike Points Way Toward More Durable COVID-19 Vaccine
Jennifer Abbasi
Closed Loop Device May Alleviate Treatment-Resistant Depression
Jennifer Abbasi
Guided Ultrasound Opens Blood-Brain Barrier to Cancer Drugs
Jennifer Abbasi
Augmented Cane Could Help People With Visual Impairments
Jennifer Abbasi
THE ARTS AND MEDICINE
Gustav Klimt’s The Kiss—Art and the Biology of Early Human Development
Dai Hyun Kim, MD, PhD; Hyunmi Park, MBChB, PhD, Med Ed; Im Joo Rhyu, MD, PhD
POETRY AND MEDICINE
Poem by a Woman With Glaucoma
Terri Kirby Erickson, BA
JAMA REVISITED
Routine Smallpox Vaccination
JAMA PATIENT PAGE
Separation Anxiety Disorder
Avani K. Patel, MD, MHA; Beverly Bryant, MD
AUDIO
Audio Editors' Summary
Dexamethasone Dose in Adults With Severe COVID-19, Mental Stress-Induced Myocardial Ischemia and Cardiovascular Events, Medicare Outcomes From the Oncology Care Model, and more
Audio Author Interview
A Continued Focus on Equity Through Pharmacoequity and Digital Health Equity: Two Current Viewpoints
VIDEO
Effect of 12 mg vs 6 mg of Dexamethasone on the Number of Days Alive Without Life Support in Adults With COVID-19 and Severe Hypoxemia
COMMENT & RESPONSE
Iatrogenic Delivery for Suspected Fetal Growth Restriction and Childhood School Outcomes
Gordon C. S. Smith, MD, PhD, DSc
Iatrogenic Delivery for Suspected Fetal Growth Restriction and Childhood School Outcomes
Niel F. Miele, MD
Iatrogenic Delivery for Suspected Fetal Growth Restriction and Childhood School Outcomes—Reply
Roshan John Selvaratnam, BMedSc(Hons); Euan Morrison Wallace, MD; Mary-Ann Davey, DPH
The Effect of Cytisine vs Varenicline on Smoking Cessation
Adam Edward Lang, PharmD
The Effect of Cytisine vs Varenicline on Smoking Cessation—Reply
Ryan J. Courtney, PhD; Piotr Tutka, MD; Michael Farrell, PhD
Medical Debt in the US From 2009 to 2020
Nishant Uppal, BS; Carrie Lubitz, MD, MPH; Benjamin James, MD, MS
Medical Debt in the US From 2009 to 2020—Reply
Neale Mahoney, PhD; Francis Wong, PhD; Wesley Yin, PhD
CORRECTION
Addition of Nonauthor Collaborator Names of the COMEBAC Study
Incorrect Patient Data Reported
JAMA MASTHEAD
JAMA
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