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IN THIS ISSUE OF JAMA
Audio Highlights
Audio Editors' Summary: Transcatheter Aortic Valve Implantation vs Surgical Replacement, Oral Methylprednisolone for IgA Nephropathy, Tracheostomy in Severe Stroke, and more
ORIGINAL INVESTIGATION
Effect of Transcatheter Aortic Valve Implantation vs Surgical Aortic Valve Replacement on All-Cause Mortality in Patients With Aortic Stenosis: A Randomized Clinical Trial
The UK TAVI Trial Investigators
Editorial: Treatment of Aortic Stenosis With Transcatheter Aortic Valve Implantation; Catherine M. Otto, MD, PhD; Jae-Kwan Song, MD
Video Editor's Note: Effect of Transcatheter Aortic Valve Implantation vs Surgical Aortic Valve Replacement on All-Cause Mortality in Patients With Aortic Stenosis
Effect of Oral Methylprednisolone on Decline in Kidney Function or Kidney Failure in Patients With IgA Nephropathy: The TESTING Randomized Clinical Trial
Jicheng Lv, MD; Muh Geot Wong, PhD; Michelle A. Hladunewich, MD; et al.
Editorial: Oral Glucocorticoids for IgA Nephropathy; Kirk N. Campbell, MD
Effect of Early vs Standard Approach to Tracheostomy on Functional Outcome at 6 Months Among Patients With Severe Stroke Receiving Mechanical Ventilation: The SETPOINT2 Randomized Clinical Trial
Julian Bösel, MD; Wolf-Dirk Niesen, MD; Farid Salih, MD; et al.
RESEARCH LETTER
Association Between SARS-CoV-2 Viral Load in Wastewater and Reported Cases, Hospitalizations, and Vaccinations in Milan, March 2020 to November 2021
Giovanni Nattino, PhD; Sara Castiglioni, PhD; Danilo Cereda, MD, PhD; et al.
Prediabetes and Diabetes Screening Eligibility and Detection in US Adults After Changes to US Preventive Services Task Force and American Diabetes Association Recommendations
Michael Fang, PhD, MHS; Dan Wang, MS; Justin B. Echouffo-Tcheugui, MD, PhD; et al.
SPECIAL COMMUNICATION
Ethical Considerations for the Inclusion of Patient-Reported Outcomes in Clinical Research: The PRO Ethics Guidelines
Samantha Cruz Rivera, PhD; Olalekan Lee Aiyegbusi, PhD; Jonathan Ives, PhD; et al.
Earn CME credit
Audio Clinical Review: Patient-Reported Outcomes in Clinical Trials
VIEWPOINT
The Imperative for Diversity and Inclusion in Clinical Trials and Health Research Participation
Kirsten Bibbins-Domingo, PhD, MD, MAS; Alex Helman, PhD; Victor J. Dzau, MD
COVID-19 Vaccination—Becoming Part of the New Normal
Peter Marks, MD, PhD; Janet Woodcock, MD; Robert Califf, MD
Getting Serious About Producing Health: The Ten Teams Challenge
Donald M. Berwick, MD, MPP
Firearm Homicide and Suicide During the COVID-19 Pandemic: Implications for Clinicians and Health Care Systems
Debra E. Houry, MD, MPH; Thomas R. Simon, PhD; Alexander E. Crosby, MD, MPH
A PIECE OF MY MIND
The Pandemic Determinants of Health
Jennifer Shiroky-Kochavi, MD, MPH
EDITORIAL
Treatment of Aortic Stenosis With Transcatheter Aortic Valve Implantation
Catherine M. Otto, MD, PhD; Jae-Kwan Song, MD
Oral Glucocorticoids for IgA Nephropathy
Kirk N. Campbell, MD
JAMA CLINICAL CHALLENGE
Ulcerated Plaques on the Scalp and Dorsal Hands of an Older Man
Amrita Goyal, MD; Daniel O’Leary, MD; Misha Rosenbach, MD
Earn CME credit
MEDICAL NEWS & PERSPECTIVES
The COVID-19 Pandemic Rages on for People Who Are Immunocompromised
Rita Rubin, MA
Resolving Payment Issues Is Essential to Realize Telehealth’s Promise
Howard D. Larkin
NEWS FROM THE FOOD AND DRUG ADMINISTRATION
First Breathalyzer Test to Diagnose COVID-19
Rita Rubin, MA
More Diversity in Clinical Trials
Rita Rubin, MA
Websites Selling Controlled Drugs Without a Prescription
Rita Rubin, MA
GLOBAL HEALTH
WHO Program May Eliminate Active Trachoma’s Blindness Risk by 2030
Howard D. Larkin
One-third of English GPs Plan to Quit Within 5 Years
Howard D. Larkin
Ukraine War Could Push an Additional 47 Million Into Acute Hunger
Howard D. Larkin
THE ARTS AND MEDICINE
Asclepius Revisited—Ancient Myth and 21st-Century Psychedelic Medicine
Richard R. Szuster, MD
POETRY AND MEDICINE
Scenes From the Children’s Hospital
Jeffrey G. Howard, PhD
JAMA REVISITED
Clinical Notes, Suggestions, and New Instruments: A Bedside Telephone
JAMA PATIENT PAGE
Psoriasis
Kristin Walter, MD, MS
AUDIO
Audio Editors' Summary
Transcatheter Aortic Valve Implantation vs Surgical Replacement, Oral Methylprednisolone for IgA Nephropathy, Tracheostomy in Severe Stroke, and more
Audio Clinical Review
Patient-Reported Outcomes in Clinical Trials
VIDEO
Video Editor's Note: Effect of Transcatheter Aortic Valve Implantation vs Surgical Aortic Valve Replacement on All-Cause Mortality in Patients With Aortic Stenosis
COMMENT & RESPONSE
Rapid Antigen Tests for SARS-CoV-2
Matheus Filgueira Bezerra, PhD
Rapid Antigen Tests for SARS-CoV-2—Reply
Joshua S. Gans, PhD; Avi Goldfarb, PhD; Laura Rosella, PhD
Penetrance of Deleterious Clinical Variants
Lisa Bastarache, MS; Josh F. Peterson, MD, MPH
Penetrance of Deleterious Clinical Variants—Reply
Iain S. Forrest, BS; Girish N. Nadkarni, MD; Ron Do, PhD
Moderate Hypothermia vs Normothermia and 30-Day Mortality in Patients With Cardiogenic Shock Receiving Venoarterial ECMO
Federico Pappalardo, MD; Andrea Montisci, MD
Moderate Hypothermia vs Normothermia and 30-Day Mortality in Patients With Cardiogenic Shock Receiving Venoarterial ECMO
Tatsuki Uemura, MD
Moderate Hypothermia vs Normothermia and 30-Day Mortality in Patients With Cardiogenic Shock Receiving Venoarterial ECMO—Reply
Bruno Levy, MD, PhD; Alain Combes, MD, PhD; Nicolas Girerd, MD, PhD
CORRECTION
Incorrect y-Axis and Panel Labels in Figure
JAMA MASTHEAD
JAMA
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