JAMA masthead Update August 29, 2026

The COVID-19 pandemic drove many changes in care delivery, and treatment of heart failure was no exception. Those shifts helped inspire an effort to apply AI to optimize chronic care treatment.

In this episode of JAMA+ AI Conversations, Haider Warraich, MD, Program Manager at the Advanced Research Projects Agency for Health and former Senior Clinical Advisor for Chronic Disease to the FDA Commissioner, speaks with JAMA+ AI Editor in Chief Roy Perlis, MD, MSc, about a program to develop FDA-authorized agentic AI systems for patients with heart failure.

He describes a vision for patient-facing AI that can monitor symptoms, triage patients, and adjust treatment between visits, with modest but thoughtful human oversight. He also discusses the challenges of safety, accountability, regulation, and clinician trust in this technology, emphasizing his belief that it must outperform current care to become widely accepted.

Listen now on Spotify | Apple Podcasts | YouTube | JAMA.com.

Editor’s Picks in this week’s JAMA+ AI:

• Recognizing the evolving influence of AI on research and scientific publishing, the editors of JAMA and JAMA Network offer updated guidance to authors for responsible use of AI. The editors describe circumstances where AI use will no longer be permitted for drafting certain manuscripts. They emphasize that authors continue to be responsible for the accuracy of all content submitted to the journal, whatever the contribution of AI. (JAMA)
• Generative AI could support public health by speeding up the timeframe for effective interventions to reach large populations, write the authors of this JAMA Viewpoint. AI makes it feasible to identify and engage people at scale and reduce administrative friction that impedes health care delivery, but this application will require cross-sector partnerships and public investments. (JAMA)
• At a certain point in the development of AI in medicine, having humans in the loop may actually worsen patient care, say the authors of this JAMA Perspective article. AI-alone medical care is likely to perform better in some cognitive aspects of medicine than physician-only or physician-AI hybrid care. The authors highlight studies suggesting AI may already be equivalent or superior to humans in these tasks. They emphasize the need to prepare for integrated workflows with autonomous AI. (JAMA)