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IN THIS ISSUE OF JAMA
Audio Highlights
Audio Editors' Summary: Semaglutide for Weight Loss, Ivermectin for Mild COVID-19, USPSTF Guideline on Screening for Vitamin D Deficiency, and more
ORIGINAL INVESTIGATION
Effect of Subcutaneous Semaglutide vs Placebo as an Adjunct to Intensive Behavioral Therapy on Body Weight in Adults With Overweight or Obesity: The STEP 3 Randomized Clinical Trial
Thomas A. Wadden, PhD; Timothy S. Bailey, MD; Liana K. Billings, MD, MMSc; et al.
Earn CME credit
Audio Clinical Review: Semaglutide for Weight Loss
Effect of Continued Weekly Subcutaneous Semaglutide vs Placebo on Weight Loss Maintenance in Adults With Overweight or Obesity: The STEP 4 Randomized Clinical Trial
Domenica Rubino, MD; Niclas Abrahamsson, MD; Melanie Davies, MD; et al.
Effect of Ivermectin on Time to Resolution of Symptoms Among Adults With Mild COVID-19: A Randomized Clinical Trial
Eduardo López-Medina, MD, MSc; Pío López, MD; Isabel C. Hurtado, MD; et al.
Earn CME credit
RESEARCH LETTER
Binding and Neutralization Antibody Titers After a Single Vaccine Dose in Health Care Workers Previously Infected With SARS-CoV-2
Saman Saadat, PhD; Zahra Rikhtegaran Tehrani, PhD; James Logue, BS; et al.
Earn CME credit
Discriminant Accuracy of the SOFA Score for Determining the Probable Mortality of Patients With COVID-19 Pneumonia Requiring Mechanical Ventilation
Robert A. Raschke, MD; Sumit Agarwal, MBBS, MBA; Pooja Rangan, MBBS, MPH; et al.
Earn CME credit
US PREVENTIVE SERVICES TASK FORCE
Recommendation Statement
Screening for Vitamin D Deficiency in Adults: US Preventive Services Task Force Recommendation Statement
US Preventive Services Task Force
Earn CME credit
Editorial: USPSTF 2021 Recommendations on Screening for Asymptomatic Vitamin D Deficiency in Adults; Sherri-Ann M. Burnett-Bowie, MD, MPH; Anne R. Cappola, MD, ScM
JAMA Network Open Editorial: Why USPSTF Still Finds Insufficient Evidence to Support Screening for Vitamin D Deficiency; Erin D. Michos, MD, MHS; Rita R. Kalyani, MD, MHS; Jodi B. Segal, MD, MPH
JAMA Patient Page: Screening for Vitamin D Deficiency in Adults; Jill Jin, MD, MPH
Evidence Report
Screening for Vitamin D Deficiency in Adults: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force
Leila C. Kahwati, MD, MPH; Erin LeBlanc, MD, MPH; Rachel Palmieri Weber, PhD; et al.
VIEWPOINT
Health Policy
How the Biden Administration Can Improve Health Equity for Racial and Ethnic Minority Populations
Karen E. Joynt Maddox, MD, MPH; Cara V. James, PhD
Conversations with Dr Bauchner: Health Care Reform in the Biden Era
COVID-19 in 2021—Continuing Uncertainty
Carlos del Rio, MD; Preeti Malani, MD, MSJ
Earn CME credit
Conversations with Dr Bauchner: Coronavirus Update With Carlos del Rio and Preeti Malani
National Initiatives to Prevent Myocardial Infarction and Stroke
Thomas R. Frieden, MD, MPH; Kathryn E. Foti, PhD, MPH
Conversations with Dr Bauchner: National Initiatives to Prevent Myocardial Infarction and Stroke
A PIECE OF MY MIND
On Mentoring
Howard Bauchner, MD
EDITORIAL
The Near-Term Future of Health Care Reform
Ezekiel J. Emanuel, MD, PhD
Crucial Questions for US Health Policy in the Next Decade
John Z. Ayanian, MD, MPP
Confronting Challenges in the US Health Care System: Potential Opportunity in a Time of Crisis
Melinda B. Buntin, PhD
The USPSTF 2021 Recommendations on Screening for Asymptomatic Vitamin D Deficiency in Adults: The Challenge for Clinicians Continues
Sherri-Ann M. Burnett-Bowie, MD, MPH; Anne R. Cappola, MD, ScM
JAMA INSIGHTS
Identifying COVID-19 Risk Through Observational Studies to Inform Control Measures
Mark W. Tenforde, MD, PhD; Kiva A. Fisher, PhD, MPH; Manish M. Patel, MD, MSc
Earn CME credit
MEDICAL NEWS & PERSPECTIVES
How the US Failed to Prioritize SARS-CoV-2 Variant Surveillance
Jennifer Abbasi
Earn CME credit
THE JAMA FORUM
Time to Rethink Nursing Homes
Stuart M. Butler, PhD
NEWS FROM THE CENTERS FOR DISEASE CONTROL AND PREVENTION
COVID-19 Precautions Are Scarce in Non–Health Care Workplaces
Bridget M. Kuehn, MSJ
Disparities in Suicide Persist Despite Overall Dip in US Rate
Bridget M. Kuehn, MSJ
BIOTECH INNOVATIONS
Data Leak Exposes Early COVID-19 Vaccine Manufacturing Hiccups
Jennifer Abbasi
Teplizumab Improves Beta Cell Function, Delays Type 1 Diabetes
Jennifer Abbasi
Wearable Bilirubin Measurement Device for Neonatal Jaundice
Jennifer Abbasi
THE ARTS AND MEDICINE
COVID-19 Postage Stamps—Messages in a Message
Bertrand Lefrère, Msc; Amélie Recoing, PharmD, MSc; Hervé Delacour, PharmD, MSc
Earn CME credit
POETRY AND MEDICINE
Winter of Fear
Allison Coffelt, MA
JAMA REVISITED
Neurology in Art
JAMA PATIENT PAGE
Screening for Vitamin D Deficiency in Adults
Jill Jin, MD, MPH
AUDIO
Audio Editors' Summary
Semaglutide for Weight Loss, Ivermectin for Mild COVID-19, USPSTF Guideline on Screening for Vitamin D Deficiency, and more
Audio Clinical Review
Effect of Space Travel on Human Health, Part 2
Audio Clinical Review: Space Travel and Human Health, Part 1: James Bagian, MD
COMMENT & RESPONSE
Effect of Early Recombinant Human Erythropoietin on Neurodevelopmental Outcomes at Age 5 Years
Hannelore Ehrenreich, MD, DVM; Achim-Peter Neubauer, MD; Kamilla Miskowiak, PhD
Effect of Early Recombinant Human Erythropoietin on Neurodevelopmental Outcomes at Age 5 Years—Reply
Giancarlo Natalucci, MD; Hans Ulrich Bucher, MD; Jean-Claude Fauchère, MD
Review of Gastroesophageal Reflux Disease
Raaj S. Mehta, MD; Kyle Staller, MD, MPH; Andrew T. Chan, MD, MPH
Review of Gastroesophageal Reflux Disease—Reply
John Maret-Ouda, MD, PhD; Sheraz R. Markar, MD, PhD; Jesper Lagergren, MD, PhD
CORRECTION
Incorrect Values in Table
JAMA MASTHEAD
JAMA
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