PHAN CHAU TRINH UNIVERSITY
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JAMA (Journal of AMA) New Issue December 16, 2025; Volume 334, Number 23

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New Issue

December 16, 2025; Volume 334, Number 23
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This Week in JAMA

Audio Highlights

Lung Cancer Screening Benefits, Peripheral Neuropathy Review, Arsenic Exposure and Mortality, and more

Original Investigation

AI in Medicine

An AI-Powered Lifestyle Intervention vs Human Coaching in the Diabetes Prevention Program: A Randomized Clinical Trial

Nestoras Mathioudakis, MD, MHS; Benjamin Lalani, BS; Mohammed S. Abusamaan, MD, MPH; et al.

Earn CME credit

Editorial: Artificial Intelligence and Diabetes Prevention; Leigh Perreault, MD

Caring for the Critically Ill Patient

Development and Validation of the Sequential Organ Failure Assessment (SOFA)-2 Score

Otavio T. Ranzani, MD, MSc, PhD; Mervyn Singer, MD; Jorge I. F. Salluh, MD, PhD; et al.

Earn CME credit

Audio: The Sequential Organ Failure Assessment (SOFA)-2 Score

Editorial: A Revision to Organ Failure Assessment in Critically Ill Patients; Christopher W. Seymour, MD, MSc

Arsenic Exposure Reduction and Chronic Disease Mortality

Fen Wu, PhD; Alexander van Geen, PhD; Joseph Graziano, PhD; et al.

Research Letter

Tracking County-Level Measles Cases in the US

Farzin Ahmadi, PhD; Ensheng Dong, PhD; Lauren M. Gardner, PhD

Emergency Medicaid Spending for Undocumented Immigrants in the US

Patricia Mae G. Santos, MD, MS; Kelsey Chalmers, PhD; Fumiko Chino, MD; et al.

Viewpoint

Advisory Committee on Immunization Practices Standards for Assessing Evidence

Doug Campos-Outcalt, MD, MPA; Jonathan Temte, MD, PhD

Women's Health

State Mifepristone Regulation Following GenBioPro v Raynes

Greer Donley, JD; Lewis A. Grossman, PhD, JD; Patricia J. Zettler, JD

Evolving Hospital-at-Home to Meet the Needs of Children

Emma Gerstenzang, MD; Aditi Vasan, MD, MSHP; Austin S. Kilaru, MD, MSHP

The Make America Healthy Again Strategy Report

Peter Lurie, MD, MPH; Lawrence O. Gostin, JD

A Piece of My Mind

The Last Night

Lenore M. Buckley, MD, MPH

Editorial

AI in Medicine

Artificial Intelligence and Diabetes Prevention

Leigh Perreault, MD

A Revision to Organ Failure Assessment in Critically Ill Patients

Christopher W. Seymour, MD, MSc

Review

Cutaneous Melanoma: A Review

Urvashi Mitbander Joshi, MD; Mohammed Kashani-Sabet, MD; John M. Kirkwood, MD

Earn CME credit

Audio: Diagnosis and Management of Cutaneous Melanoma

JAMA Guide to Statistics and Methods

Pattern-Mixture Models for Missing Data

Roderick J. Little, PhD

Earn CME credit

JAMA Insights

Recurrent Clostridioides difficile Infections

Joffrey van Prehn, MD, PhD; Ed J. Kuijper, MD, PhD; Erik R. Dubberke, MD, MSPH

Earn CME credit

Editor's Note

AI in Medicine

AI in the Lab—Will It Really Change Drug Discovery?

Roy Perlis, MD, MSc

Audio: AI for Drug Discovery

“How Strangely Sweet”: Laryngitis and the Quiet Quirkiness of Senryu

Rafael Campo, MD, MA

Medical News

New Insights on Circadian Health and Cardiometabolic Disease—Light, Sleep, Food, Exercise, and More

Kate Schweitzer

Quick Uptakes

Gluten Sensitivity Is Common Around the World—Explanations Are Emerging

Samantha Anderer

Medical News in Brief

2024-2025 COVID-19 Vaccines Protected Against JN.1 Subvariants

Shravya Pant

FDA Approves Nonhormonal Treatment for Menopausal Hot Flashes

Shravya Pant

Meta-Analysis: Viral Infections May Raise Cardiovascular Risks

Shravya Pant

Bacterial Vaginosis Treatment Should Involve All Partners, ACOG Says

Shravya Pant

Updated Flu, RSV Vaccination Recommendations for Immunocompromised People

Shravya Pant

AAP: Leucovorin Not Recommended for Autism

Shravya Pant

Poetry and Medicine

Hush

John Savoie, PhD

Editor's Note: “How Strangely Sweet”: Laryngitis and the Quiet Quirkiness of Senryu; Rafael Campo, MD, MA

JAMA Revisited

Sunshine and Health

JAMA Patient Page

Early-Onset Gastrointestinal Cancer

Krista Roberts, MD

Audio

Lung Cancer Screening Benefits, Peripheral Neuropathy Review, Arsenic Exposure and Mortality, and more

The Sequential Organ Failure Assessment (SOFA)-2 Score

Diagnosis and Management of Cutaneous Melanoma

AI for Drug Discovery

Comment & Response

Telehealth and Online Cognitive Behavioral Therapy–Based Treatments for High-Impact Chronic Pain

Yilin Jiang, PhD; Narina A. Samah, PhD; Heng Zhou, MSc

Telehealth and Online Cognitive Behavioral Therapy–Based Treatments for High-Impact Chronic Pain

Dandan Xu, MM; Ran Chen, MD; Hongjian Shan, MD

Telehealth and Online Cognitive Behavioral Therapy–Based Treatments for High-Impact Chronic Pain—Reply

Lynn L. DeBar, PhD, MPH; Andrea J. Cook, PhD; Francis J. Keefe, PhD

Review on Uveitis

Steven Oscherwitz, MD

Review on Uveitis—Reply

Panayiotis Maghsoudlou, PhD; Andrew D. Dick, MD

Lower Urinary Tract Symptoms in Males

Zhigui Zheng, MD; Xinxin Jiang, MD; Binbin Wu, MD

Lower Urinary Tract Symptoms in Males

Sanjay Sinha, MCh; Pawan Vasudeva, MCh

Lower Urinary Tract Symptoms in Males

Jean-Nicolas Cornu, MD, PhD; Benoit Peyronnet, MD, PhD; Cosimo De Nunzio, MD, PhD

Lower Urinary Tract Symptoms in Males—Reply

John T. Wei, MD, MS; Casey Dauw, MD; Casey Brodsky, MD, PhD

JAMA Masthead

JAMA


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