JAMA + AI Top Audio 2025 January 10, 2026

Designing AI for Uncertainty: A Conversation With Eric Horvitz

How can AI systems reason safely in the open world of medicine? JAMA+ AI Associate Editor Yulin Hswen, ScD, MPH, talks with Eric Horvitz, MD, PhD, Chief Scientific Officer at Microsoft, about the future of AI in 5 years to 100 years and how we can guide AI to be copilots while maintaining integrity and safety in the clinical arena.

They explore how decades of work in probabilistic modeling and human AI collaboration inform today’s research questions and what that means for authorship, trust, and innovation. The conversation looks backward and forward, exploring how AI can both diminish and rekindle independent thought.

AI, Health, and Health Care

Derek Angus, MD, MPH, joins JAMA+ AI Editor in Chief Roy Perlis, MD, MSc, to discuss a special communication from the JAMA Summit on Artificial Intelligence.

The Report, authored by over 50 experts in AI, defines current AI tools in health and health care, explains challenges for their regulation, evaluation, and responsible use, and concludes with potential solutions and implications for the health care workforce.

Maintaining Safety and Trust When Patients Engage Google: A Conversation With Dr Michael Howell

How is Google Search evolving with AI and how do we ensure that language models maintain safety? JAMA+ AI Editor in Chief Roy Perlis, MD, MSc, talks with Michael Howell, MD, MPH, Google’s Chief Health Officer, about how he aims to balance innovation and safety in AI-driven medicine, building on his own work in hospital-based quality and safety.

Navigating Transparency and Trust With AI in Health Care

Michelle Mello, JD, PhD, MPhil, professor of law and health policy at Stanford University, joins JAMA+ AI Editor in Chief Roy Perlis, MD, MSc, to discuss her JAMA Perspective that lays out a framework for when and how health care organizations should disclose AI use to patients.

Dr Mello shares insights on the importance of patient trust and surveys that suggest many patients currently mistrust the use of AI in their care.

Older Adults’ Use of Digital Health Technology

Digital health technologies, including patient portals, are widely used by older adults, as described in a recent study published in JAMA Network Open. Author Cornelius James, MD, of the University of Michigan joins JAMA+ AI Editor in Chief Roy H. Perlis, MD, MSc, to discuss the study and how it fits with his own experience in the clinic.

AI-Based Suicide Screening for American Indian Patients

American Indian and Alaska Native communities have higher rates of suicide than any other racial or ethnic group in the US. A study published in JAMA Network Open describes an AI-based suicide screening tool investigated in an American Indian community. Author Emily Haroz, PhD, of Johns Hopkins Bloomberg School of Public Health, joins JAMA and JAMA+ AI Associate Editor Yulin Hswen, ScD, MPH.

Should Employers Offer Digital Mental Health Programs to Support Workforce Well-Being?

Employer-sponsored digital health solutions help patients with behavioral health conditions increase workplace productivity. Yulin Hswen, ScD, MPH, Associate Editor of JAMA+ AI, spoke with Molly Candon, PhD, and Adam Chekroud, PhD, about their work published in JAMA Network Open evaluating the financial return on investment for companies participating in these AI health care programs.

Language Equity in Health Technology

AI can play a role in addressing language barriers in health care. In an Editorial in JAMA Network Open, Pilar Ortega, MD, MGM, of the University of Illinois College of Medicine, and coauthors emphasize the urgent need for integrating language equity into digital health solutions. Dr Ortega joins JAMA and JAMA+ AI Associate Editor Yulin Hswen, ScD, MPH, to discuss.