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JAMA + AI Weekly Update March 15, 2025

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Weekly Update

March 15, 2025
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Recruiting patients for clinical trials is a costly and time-consuming process. Could AI help?

In a new JAMA+ AI Conversations, we talked with Mass General Brigham’s Alexander Blood about his LLM tool designed to assess patient eligibility more accurately and efficiently than manual screening.

Also this week:

  • JAMA Viewpoint laid out the genesis of Trustworthy and Responsible AI Network (TRAIN) and strategies for ensuring effective and safe use of AI throughout the US health care system.
  • JAMA research letter by Blood et al. found that AI-assisted patient screening improved the rate of eligibility determination and enrollment compared with manual screening in a heart failure trial.
  • An invited commentary published in JAMA Network Open reflected on a study of an employer-sponsored digital health platform.

Medical News & Perspectives

JAMA

Study Finds AI Can Quickly Prescreen Patients for Clinical Trials, Speeding Enrollment

Yulin Hswen, ScD, MPH; Nora Collins

INVITED COMMENTARY

JAMA Network Open

Employer-Sponsored Digital Health Platforms for Mental Wellness—A Good Investment

Molly Candon, PhD; Rebecca E. Stewart, PhD

RESEARCH LETTER

JAMA

Manual vs AI-Assisted Prescreening for Trial Eligibility Using Large Language Models—A Randomized Clinical Trial

Ozan Unlu, MD; Matthew Varugheese, MS; Jiyeon Shin, BS, ALM; et al

VIEWPOINT

JAMA

Launching the Trustworthy and Responsible AI Network (TRAIN): A Consortium to Facilitate Safe and Effective AI Adoption

Peter J. Embí, MD, MS; David C. Rhew, MD; Eric D. Peterson, MD, MPH; et al

AUDIO

 Prescreening for Clinical Trial Eligibility Using Large Language Models

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