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IN THIS ISSUE OF JAMA
Audio Highlights
Audio Editors' Summary: Higher-Dose Ivermectin for Outpatients With COVID-19, Trends in Cardiovascular Risk Factor Prevalence and Control in US Adults, Review of Chronic Lymphocytic Leukemia, and more
ORIGINAL INVESTIGATION
Effect of Higher-Dose Ivermectin for 6 Days vs Placebo on Time to Sustained Recovery in Outpatients With COVID-19: A Randomized Clinical Trial
Susanna Naggie, MD, MHS; David R. Boulware, MD, MPH; Christopher J. Lindsell, PhD; et al.
Editorial: The Ethics of Clinical Research: Managing Persistent Uncertainty ; Alex John London, PhD; Christopher W. Seymour, MD, MSc
Editor's Note: At a Higher Dose and Longer Duration, Ivermectin Still Not Effective Against COVID-19 ; Kirsten Bibbins-Domingo, PhD, MD, MAS; Preeti N. Malani, MD, MSJ
Cardiovascular Risk Factor Prevalence, Treatment, and Control in US Adults Aged 20 to 44 Years, 2009 to March 2020
Rahul Aggarwal, MD; Robert W. Yeh, MD, MSc; Karen E. Joynt Maddox, MD, MPH; et al.
Editorial: The Urgent Need to Refocus Cardiovascular Disease Prevention Efforts on Young Adults; Norrina Allen, PhD, MPH; John T. Wilkins, MD, MSc
Early vs Interval Postpartum Intrauterine Device Placement: A Randomized Clinical Trial
Sarah Averbach, MD; Gennifer Kully, MSc; Erica Hinz, MD; et al.
RESEARCH LETTER
Ectopic Pregnancy Risk in Users of Levonorgestrel-Releasing Intrauterine Systems With 52, 19.5, and 13.5 mg of Hormone
Amani Meaidi, MD, PhD; Christian Torp-Pedersen, MD, MMSc; Øjvind Lidegaard, MD, DMSc; et al.
Prevalence and County-Level Distribution of Births in Catholic Hospitals in the US in 2020
Alice F. Cartwright, MPH; Brooke W. Bullington, BA; Kavita Shah Arora, MD; et al.
Invited Commentary: Catholic Hospitals, Patient Autonomy, and Sexual and Reproductive Health Care in the United States; Lindsay K. Admon, MD, MSc; Jennifer Villavicencio, MD
VIEWPOINT
Roe v Wade’s 50th Anniversary: New Legal Frontiers for Safeguarding Reproductive Freedoms
Rebecca B. Reingold, JD; Lawrence O. Gostin, JD
Editorial: Health Care Access and Reproductive Rights; Linda Brubaker, MD, MS; Kirsten Bibbins-Domingo, MD, PhD, MAS
Time to Abolish Metrics That Sustain Systemic Racism in Kidney Allocation
John S. Gill, MD, MS; Burnett Kelly, MD, MBA; Marcello Tonelli, MD, SM
Redressing the Harms of Race-Based Kidney Function Estimation
Dinushika Mohottige, MD, MPH; Tanjala S. Purnell, PhD, MPH; L. Ebony Boulware, MD, MPH
Audio: Race-Neutral Estimates of Kidney Function: Enhancing Equity
Video: Race-Neutral Estimates of Kidney Function: Enhancing Equity
A PIECE OF MY MIND
Listening Lessons
Brittany A. Bettendorf, MD, MFA
EDITORIAL
The Ethics of Clinical Research: Managing Persistent Uncertainty
Alex John London, PhD; Christopher W. Seymour, MD, MSc
The Urgent Need to Refocus Cardiovascular Disease Prevention Efforts on Young Adults
Norrina Allen, PhD, MPH; John T. Wilkins, MD, MSc
REVIEW
Diagnosis and Treatment of Chronic Lymphocytic Leukemia: A Review
Mazyar Shadman, MD, MPH
Earn CME credit
Audio: Diagnosis and Management of Chronic Lymphocytic Leukemia
JAMA INSIGHTS
Women's Health
Perforation During Gynecological Procedures
Elliott G. Richards, MD, PhD; Jenna M. Rehmer, MD; Tommaso Falcone, MD
Earn CME credit
EDITOR'S NOTE
At a Higher Dose and Longer Duration, Ivermectin Still Not Effective Against COVID-19
Kirsten Bibbins-Domingo, PhD, MD, MAS; Preeti N. Malani, MD, MSJ
Editorial: The Ethics of Clinical Research: Managing Persistent Uncertainty ; Alex John London, PhD; Christopher W. Seymour, MD, MSc
MEDICAL NEWS & PERSPECTIVES
Race-Based Equations Delayed Black Patients From Getting Onto Kidney Transplant Lists—An Unprecedented New Policy Seeks to Undo the Damage
Jennifer Abbasi
Audio: Race-Neutral Estimates of Kidney Function: Enhancing Equity
Video: Race-Neutral Estimates of Kidney Function: Enhancing Equity
NEWS FROM THE JAMA NETWORK
Large Study Finds Women Are (Still) Much More Likely to Die or Have Complications After Coronary Artery Bypass Graft Surgery Than Men
Kate Ruder, MSJ
MEDICAL NEWS IN BRIEF
Meta-analysis: COVID-19 Infection Protects Against Severe Disease
Emily Harris
Prior COVID-19 Infection Tied to Lasting Lung Abnormalities
Emily Harris
Study: Breast Radiotherapy Does Not Improve Survival in Older Patients
Emily Harris
On-Demand Male Contraceptive Compound Promising in Mouse Study
Emily Harris
Chronic Pain at Multiple Sites Tied to Increased Dementia Risk
Emily Harris
ADHD Drugs in Pregnancy Not Linked to Children’s Brain Development
Emily Harris
Nursing Homes Required to Reveal Ownership Status Under Proposed Rule
Emily Harris
Majority of Infant Formula Health Claims Are Poorly Supported
Emily Harris
Patients With Normal Gut Biopsy Still at Increased Risk of IBD
Emily Harris
POETRY AND MEDICINE
Mildly Hypercalcemic
Eve Rittenberg, MD
JAMA REVISITED
Noah Webster as Epidemiologist
JAMA PATIENT PAGE
What Is Melanoma?
Jennifer Y. Wang, MD; Erica B. Wang, MD; Susan M. Swetter, MD
AUDIO
Audio Editors' Summary
Higher-Dose Ivermectin for Outpatients With COVID-19, Trends in Cardiovascular Risk Factor Prevalence and Control in US Adults, Review of Chronic Lymphocytic Leukemia, and more
Audio Author Interview
Race-Neutral Estimates of Kidney Function: Enhancing Equity
Clinical Reviews Audio
Diagnosis and Management of Chronic Lymphocytic Leukemia
VIDEO
JAMA Video
Race-Neutral Estimates of Kidney Function: Enhancing Equity
COMMENT & RESPONSE
Preoperative Hemodialysis Timing and Postoperative Mortality in Patients With End-stage Kidney Disease
Nirvik Pal, MBBS, MD; Miklos D. Kertai, MD, PhD; Mark Nelson, MD
Preoperative Hemodialysis Timing and Postoperative Mortality in Patients With End-stage Kidney Disease—Reply
Vikram Fielding-Singh, MD, JD; Matthew W. Vanneman, MD; Eugene Lin, MD, MS
Hormone Therapy for the Prevention of Chronic Conditions in Postmenopausal Persons
Margaret Nachtigall, MD; Richard Nachtigall, MD; Lila Nachtigall, MD
Hormone Therapy for the Prevention of Chronic Conditions in Postmenopausal Persons
Sarah Glynne, BSc, MBBS, MSc; Louise Newson, MBChB, MCRP; Dan Reisel, MBBS, MSc, DPhil
Hormone Therapy for the Prevention of Chronic Conditions in Postmenopausal Persons
Garnet L. Anderson, PhD
Hormone Therapy for the Prevention of Chronic Conditions in Postmenopausal Persons
Rowan T. Chlebowski, MD, PhD; Aaron K. Aragaki, MS
Hormone Therapy for the Prevention of Chronic Conditions in Postmenopausal Persons—Reply
Carol M. Mangione, MD, MSPH; Wanda Nicholson, MD, MPH, MBA; James Stevermer, MD, MSPH
Hormone Therapy for the Prevention of Chronic Conditions in Postmenopausal Persons—Reply
Gerald Gartlehner, MD, MPH; Leila Kahwati, MD, MPH
CORRECTION
Incomplete Information in Table
JAMA MASTHEAD
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