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IN THIS ISSUE OF JAMA
Audio Highlights
Audio Editors' Summary: Helmet Ventilation for COVID-19, Rheumatoid Arthritis and Immune-Mediated Inflammatory Disease Treatment, Diagnosis and Management of Stable Angina, and more
ORIGINAL INVESTIGATION
α2-Adrenergic Agonists or Stimulants for Preschool-Age Children With Attention-Deficit/Hyperactivity Disorder
Elizabeth Harstad, MD, MPH; Justine Shults, PhD; William Barbaresi, MD; et al
Editorial: Comparison of Medication Treatments for Preschool Children With ADHD; Tanya E. Froehlich, MD, MS
Caring for the Critically Ill Patient
Effect of Helmet Noninvasive Ventilation vs High-Flow Nasal Oxygen on Days Free of Respiratory Support in Patients With COVID-19 and Moderate to Severe Hypoxemic Respiratory Failure: The HENIVOT Randomized Clinical Trial
Domenico Luca Grieco, MD; Luca S. Menga, MD; Melania Cesarano, MD; et al.
Earn CME credit
Video: Noninvasive Ventilation of COVID-19 Patients
Conversations with Dr Bauchner: Noninvasive Ventilation of COVID-19 Patients
Editorial: Respiratory Support During the COVID-19 Pandemic: Is It Time to Consider Using a Helmet?; Laveena Munshi, MD; Jesse B. Hall, MD
Effect of Therapeutic Drug Monitoring vs Standard Therapy During Infliximab Induction on Disease Remission in Patients With Chronic Immune-Mediated Inflammatory Diseases: A Randomized Clinical Trial
Silje Watterdal Syversen, MD, PhD; Guro Løvik Goll, MD, PhD; Kristin Kaasen Jørgensen, MD, PhD; et al.
Earn CME credit
Editorial: Treatment Strategies for Patients With Immune-Mediated Inflammatory Diseases; Jeffrey R. Curtis, MD, MS, MPH; Alexis Ogdie, MD, MSCE; Michael D. George, MD, MSCE
Effect of Half-Dose vs Stable-Dose Conventional Synthetic Disease-Modifying Antirheumatic Drugs on Disease Flares in Patients With Rheumatoid Arthritis in Remission: The ARCTIC REWIND Randomized Clinical Trial
Siri Lillegraven, MD, MPH, PhD; Nina Paulshus Sundlisæter, MD, PhD; Anna-Birgitte Aga, MD, PhD; et al.
Earn CME credit
Editorial: Treatment Strategies for Patients With Immune-Mediated Inflammatory Diseases; Jeffrey R. Curtis, MD, MS, MPH; Alexis Ogdie, MD, MSCE; Michael D. George, MD, MSCE
RESEARCH LETTER
Immunogenicity of a Single Dose of SARS-CoV-2 Messenger RNA Vaccine in Solid Organ Transplant Recipients
Brian J. Boyarsky, MD; William A. Werbel, MD; Robin K. Avery, MD; et al.
Earn CME credit
Excess Deaths From COVID-19 and Other Causes in the US, March 1, 2020, to January 2, 2021
Steven H. Woolf, MD, MPH; Derek A. Chapman, PhD; Roy T. Sabo, PhD; et al.
Earn CME credit
Editorial: Learning From Excess Pandemic Deaths; Alan M. Garber, MD, PhD
Trends in the Prevalence of Concussion Reported by US Adolescents, 2016-2020
Phil Veliz, PhD; Sean Esteban McCabe, PhD; James T. Eckner, MD, MS; et al.
VIEWPOINT
Implementing High-Quality Primary Care: A Report From the National Academies of Sciences, Engineering, and Medicine
Robert L. Phillips Jr, MD, MSPH; Linda A. McCauley, RN, PhD; Christopher F. Koller, MA
Reducing Low-Value Care and Improving Health Care Value
Allison H. Oakes, PhD; Thomas R. Radomski, MD, MS
Evaluation of Aducanumab for Alzheimer Disease: Scientific Evidence and Regulatory Review Involving Efficacy, Safety, and Futility
G. Caleb Alexander, MD, MS; Scott Emerson, MD, PhD; Aaron S. Kesselheim, MD, JD, MPH
Revised UNAIDS/WHO Ethical Guidance for HIV Prevention Trials
Rieke van der Graaf, PhD; Andreas Reis, MD, MSc; Peter Godfrey-Faussett, MBBS
A PIECE OF MY MIND
The Silent Mutation
Margo A. Peyton, BA
EDITORIAL
Comparison of Medication Treatments for Preschool Children With ADHD: A First Step Toward Addressing a Critical Gap
Tanya E. Froehlich, MD, MS
Respiratory Support During the COVID-19 Pandemic: Is It Time to Consider Using a Helmet?
Laveena Munshi, MD; Jesse B. Hall, MD
Earn CME credit
Treatment Strategies for Patients With Immune-Mediated Inflammatory Diseases
Jeffrey R. Curtis, MD, MS, MPH; Alexis Ogdie, MD, MSCE; Michael D. George, MD, MSCE
Learning From Excess Pandemic Deaths
Alan M. Garber, MD, PhD
Earn CME credit
REVIEW
Diagnosis and Management of Stable Angina: A Review
Parag H. Joshi, MD, MHS; James A. de Lemos, MD
Earn CME credit
Audio Clinical Review: Chronic Stable Angina—Diagnosis and Treatment
JAMA INSIGHTS
The Importance of Delirium and Delirium Prevention in Older Adults During Lockdowns
Sharon K. Inouye, MD, MPH
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Women's Health
Risk-Reducing Mastectomy
Ismail Jatoi, MD, PhD; Zoe Kemp, MD, PhD
Invited Commentary: Mastectomy or Breast-Conserving Therapy for BRCA1/2 Variant Carriers; Marissa Howard-McNatt, MD
MEDICAL NEWS & PERSPECTIVES
Pandemic Boosts an Old Idea—Bringing Acute Care to the Patient
Mary Chris Jaklevic, MSJ
Earn CME credit
A Partnership With the Cherokee Nation Advances Medical Education on Tribal Land
Mary Chris Jaklevic, MSJ
JAMA Medical News Audio: A Partnership With the Cherokee Nation Advances Medical Education on Tribal Land
JAMA Live Highlights
Experts Discuss COVID-19—Variants and Vaccine Efficacy, Immunosuppressed Patients, and More
Earn CME credit
JAMA Medical News Audio: April 2021 Medical News Summary
NEWS FROM THE FOOD AND DRUG ADMINISTRATION
Cell-Based Gene Therapy Is New Option for Multiple Myeloma
Rebecca Voelker, MSJ
Pioneering Heart Valve Approved for Patients With CHD
Rebecca Voelker, MSJ
Electrical Stimulator Can Improve MS-Related Walking Problems
Rebecca Voelker, MSJ
POETRY AND MEDICINE
Lies Before Retirement
Michael Salcman, MD
JAMA REVISITED
BOOK REVIEWS
JAMA PATIENT PAGE
Surgery for Breast Cancer Prevention
Ismail Jatoi, MD, PhD; Zoe Kemp, MD, PhD
AUDIO
Audio Editors' Summary
Helmet Ventilation for COVID-19, Rheumatoid Arthritis and Immune-Mediated Inflammatory Disease Treatment, Diagnosis and Management of Stable Angina, and more
Audio Clinical Review
Chronic Stable Angina—Diagnosis and Treatment
JAMA Medical News Audio
April 2021 Medical News Summary
COMMENT & RESPONSE
Effect of Adjuvant Metronomic Capecitabine on Disease-Free Survival Among Patients With Early-Stage Triple-Negative Breast Cancer
Feng Du, MD; Peng Yuan, MD
Effect of Adjuvant Metronomic Capecitabine on Disease-Free Survival Among Patients With Early-Stage Triple-Negative Breast Cancer
Deep Chakrabarti, MD; Naseem Akhtar, MCh; Vijay Kumar, MCh
Effect of Adjuvant Metronomic Capecitabine on Disease-Free Survival Among Patients With Early-Stage Triple-Negative Breast Cancer—Reply
Xi-Wen Bi, MD; Xin Hua, MD; Zhong-Yu Yuan, MD
Management of Crohn Disease
Ahmed B. Bayoumy, BSc, BPharm; Nanne K. H. de Boer, MD, PhD; Chris J. J. Mulder, MD, PhD
Management of Crohn Disease—Reply
Kelly Cushing, MD, MSCI; Peter D. R. Higgins, MD, PhD, MSc
CORRECTION
Incorrect P Value and Figure Label Error
JAMA MASTHEAD
JAMA
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