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JAMA Most Read This Week OCTOBER 12, 2025

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Most Read This Week

October 12, 2025

These articles were most popular among readers in the last week. Click below to read them for free.

JAMA

News & Insight

Acetaminophen Use in Pregnancy—Study Author Explains the Data

Kate Schweitzer

News & Insight

Trying to Unravel Why Alzheimer Disease Is More Common in Women

Rita Rubin, MA

News & Insight

Seven Takeaways From the MAHA Children’s Health Strategy

Samantha Anderer

Research

Inhaler-Related Greenhouse Gas Emissions in the US: A Serial Cross-Sectional Analysis

William B. Feldman, MD, DPhil, MPH; Jihye Han, PharmD, MPH; Adam J. N. Raymakers, PhD; et al

News & Insight

The Complexity of Research on Moderate Alcohol Consumption and Health: The Consensus Report From NASEM

Ned Calonge, MD, MPH; Ian J. Saldanha, MBBS, MPH, PhD; Katrina B. Stone, PhD

JAMA Cardiology

Research

Intracardiac vs Transesophageal Echocardiography in Atrial Fibrillation Ablation: A Randomized Clinical Trial

Xiaofeng Hu, MD; Weifeng Jiang, MD; Xinhua Wang, MD; et al

Opinion

How Cardiovascular Health in Young Adulthood Affects Kidney and Cardiovascular Risk Later in Life—Lifespan Lessons

Sarah Haeger, MD, PhD; Nisha Bansal, MD, MAS

Research

Cumulative Cardiovascular Health Score Through Young Adulthood and Cardiovascular and Kidney Outcomes in Midlife

Jong Hyun Jhee, MD, PhD; Kyoung Hwa Ha, PhD; Dasom Son, BS; et al

JAMA Dermatology

News & Insight

Approach to Scarring Alopecia

Jiana Wyche, MHS; Maryanne Senna, MD; Crystal Aguh, MD

Opinion

Navigating Melanoma In Situ in the Age of Overdiagnosis

Yaelle Shaked, MS; Alyssa Swearingen, MD; Jennifer A. Stein, MD, PhD; et al

Research

Successful Treatment of Alopecia Areata With One JAK Inhibitor After Failure of Other JAK Inhibitors

Luiza Kalil, MD; Brittany G. Craiglow, MD; Brett King, MD, PhD

JAMA Health Forum

Research

Clinical Quality Performance of Value-Based and Fee-for-Service Models for Medicare Advantage

Eleanor M. Beltz, PhD; Kelly J. Thomas Craig, PhD; Wei Xin, PhD; et al

Research

Benefit-Risk Reporting for FDA-Cleared Artificial Intelligence−Enabled Medical Devices

John C. Lin, BS; Bhav Jain, BS; Jay M. Iyer, BA; et al

Opinion

The Importance of Health Equity Scholarship in Uncertain Times

Ninez A. Ponce, PhD, MPP; Sugy Choi, PhD, MS; Sandro Galea, MD, DrPH

JAMA Internal Medicine

Clinical Review & Education

The Rise in Early-Onset Cancer in the US Population—More Apparent Than Real

Vishal R. Patel, MD, MPH; Adewole S. Adamson, MD, MPP; H. Gilbert Welch, MD, MPH

Research

Using the PREVENT Equations to Guide Aspirin Use for Primary Prevention of Cardiovascular Disease

Ahmed Sayed, MBBS; Eric D. Peterson, MD, MPH; Amit Khera, MD, MSc; et al

Opinion

Overdiagnosis of Cancer—Not Only Associated With Aging

Ilana B. Richman, MD, MHS; Cary P. Gross, MD

JAMA Network Open

Research

In-Flight Medical Events on Commercial Airline Flights

Paulo M. Alves, MD; Karan R. Kumar, MD; Justin Devlin, MD; et al

Research

Use of Ambient AI Scribes to Reduce Administrative Burden and Professional Burnout

Kristine D. Olson, MD, MSc; Daniella Meeker, PhD; Matt Troup, PA-C; et al

Research

Memantine to Treat Social Impairment in Youths With Autism Spectrum Disorder: A Randomized Clinical Trial

Gagan Joshi, MD; Atilla Gönenc, PhD; Maura DiSalvo, MPH; et al

JAMA Neurology

Research

Optimal Antithrombotics for Ischemic Stroke and Concurrent Atrial Fibrillation and Atherosclerosis: A Randomized Clinical Trial

Shuhei Okazaki, MD; Kanta Tanaka, MD; Yukako Yazawa, MD; et al

Opinion

Anticoagulation and Antiplatelet Therapy in Patients With Atrial Fibrillation and Atherosclerosis

Richard A. Bernstein, MD, PhD; Lauren E. Previch, MD

Research

Menopause Impact on Multiple Sclerosis Disability Progression

Francesca Bridge, MBBS; Paul G. Sanfilippo, PhD; Chao Zhu, PhD; et al

JAMA Oncology

Research

Prostate-Specific Membrane Antigen PET-Guided Intensification of Salvage Radiotherapy After Radical Prostatectomy: A Phase 2 Randomized Clinical Trial

Colin Belliveau, MD; Fred Saad, MD; Danny Duplan, MD; et al

Research

The Definition of Cure in Colon Cancer: A Pooled Analysis of 15 Randomized Clinical Trials

Alessandro Pastorino, MD; Heshan Liu, MS; Levi Pederson, MS; et al

Opinion

Contraceptive Choices for Premenopausal Women and Breast Cancer Risk

Meghna Gaddam, BA; Mitchell D. Creinin, MD; David Victorson, PhD; et al

JAMA Ophthalmology

Research

Vitreous Floaters Functional Questionnaire for Vision-Degrading Myodesopsia From Vitreous Floaters

Justin H. Nguyen, BA; Stefaniya K. Boneva, MD; Jeannie Nguyen-Cuu, DO; et al

Opinion

Patient-Centered Care in Symptomatic Floaters

Louay Almidani, MD, MSc; Pradeep Ramulu, MD, PhD

Research

Predicting Spaceflight-Associated Neuro-Ocular Syndrome in International Space Station Astronauts

Tyson J. Brunstetter, OD, PhD; Sara S. Mason, BS; Suzi Osborne, MPH; et al

JAMA Otolaryngology - Head & Neck Surgery

Research

Partial vs Whole Laryngeal Radiotherapy for Clinical Stage T1-2N0M0/Tis Laryngeal Carcinoma

Teeradon Treechairusame, MD; Edward Christopher Dee, MD; Caineng Cao, MD; et al

Clinical Review & Education

Head and Neck Cancer Salvage Surgery in the Era of Immunotherapy and Beyond: A Review

Nabil F. Saba, MD; Nader G. Zalaquett, BS; Saad Rashid, MD; et al

Research

Factors Associated With Dizziness Among Patients With Vestibular Schwannoma

Tyler Wilson, MSCI; Dorina Kallogjeri, MD, MPH; Belinda Sinks, AuD; et al

JAMA Pediatrics

Research

Reevaluating Nonoperative Management for Pediatric Uncomplicated Acute Appendicitis: A Systematic Review and Meta-Analysis

Isabella Faria, MD; Ana Carolina Godinho Cintra; Luiz Gustavo Albuquerque Mello de Oliveira; et al

Research

Population-Level Effectiveness and Herd Protection 17 Years After HPV Vaccine Introduction

Aislinn DeSieghardt, MS; Lili Ding, PhD; Aaron Ermel, MD; et al

Clinical Review & Education

Suicide Interventions for Youths: A Systematic Review

Leslie Sim, PhD, LP; M. Hassan Murad, MD, MPH; Paul E. Croarkin, DO, MS; et al

JAMA Psychiatry

Research

Early Dose Reduction or Discontinuation vs Maintenance Antipsychotics After First Psychotic Episode Remission: A Randomized Clinical Trial

Iris E. Sommer, MD, PhD; Franciska de Beer, MSc; Shiral Gangadin, PhD; et al

Research

Measures of General Intelligence and Risk for Alcohol Use Disorder

Andrea Johansson Capusan, MD, PhD; Christal N. Davis, PhD; Emelie Thern, PhD; et al

Research

Heart Rate Variability Biofeedback for Substance Use Disorder: A Randomized Clinical Trial

David Eddie, PhD, ABPP; Marina Nguyen, BS; Katherine Zeng, BS; et al

JAMA Surgery

Research

Child and Adolescent Firearm-Related Homicide Occurring at Home

Jordan M. Rook, MD, PhD; Whitney Orji, MD, MS; Savannah C. Walker, MD; et al

Research

Non–β-Lactam Antibiotic Use, β-Lactam Allergy, and Surgical Site Infections

Prateek Agarwal, MD, MBA; Rohit Prem Kumar, MD; Louise-Marie Oleksiuk, PharmD; et al

Research

Minimally Invasive vs Open Left Pancreatectomy for Resectable Pancreatic Cancer: Long-Term Results of the Randomized DIPLOMA Trial

Caro L. Bruna, MD; Jony van Hilst, MD; Maarten Korrel, MD; et al

Most Listened to Audio

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Acetaminophen Use in Pregnancy and Risk of Autism

Five Things to Do When Communicating Medical Numbers

Superficial Vein Thrombosis

Treatment of Severe Refractory Asthma

Diagnosis and Management of Hypothyroidism

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