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JAMA Internal Medicine New Issue January 2026; Volume 186, Number 1

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New Issue

January 2026; Volume 186, Number 1
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Viewpoint

AI and Clinical Care

Software as a Medical Practitioner—Is It Time to License Artificial Intelligence?

Eric Bressman, MD, MSHP; Carmel Shachar, JD, MPH; Ariel D. Stern, PhD; et al.

Editorial: Applying Clinical Licensure Principles to Artificial Intelligence; Eve Rittenberg, MD, MA; Roy Perlis, MD, MSc; Sharon Inouye, MD, MPH

Health Care Policy and Law

Inhaler Price Caps—Patchwork Progress Without Reform

Stephen A. Mein, MD; Rishi K. Wadhera, MD, MPP, MPhil

Inside Story

The Letters Not Sent

Henry Bair, MD

AI and Clinical Care

Scientific Writing in the Age of Artificial Intelligence

John F. Steiner, MD, MPH

Editor's Note: Satisfaction in Writing; Deborah Grady, MD, MPH; Eve Rittenberg, MD, MA

Original Investigation

Aging and Health

Online Unsupervised Tai Chi Intervention for Knee Pain and Function in People With Knee Osteoarthritis: The RETREAT Randomized Clinical Trial

Shiyi Julia Zhu, BPhysio; Rana S. Hinman, PhD; Rachel K. Nelligan, PhD; et al.

Editor's Note: Online Digital Health Intervention—Safe and Scalable; Justin J. Choi, MD, MSc; Sharon K. Inouye, MD, MPH; Lona Mody, MD, MSc

Women's Health

Pragmatic Interventions to Boost Surveillance Mammogram Uptake Among an Overdue Population: A Randomized Clinical Trial

Soo-Chin Lee, MMed; Sasidharan Swarnalatha Lucky, PhD; Junxian Zhu, PhD; et al.

Effectiveness and Cost-Effectiveness of Automated External Defibrillators in Private Homes: A Report From the Cardiac Arrest Registry to Enhance Survival

Lars W. Andersen, MD, MPH, PhD, DMSc; Mathias J. Holmberg, MD, MPH, PhD; Eline Krijkamp, PhD; et al.

Liraglutide in Acute Minor Ischemic Stroke or High-Risk Transient Ischemic Attack With Type 2 Diabetes: The LAMP Randomized Clinical Trial

Huili Zhu, MD; Bin Yang, MD; Longyan Lu, MMed; et al.

Health Equity

Community Health Worker Support for Hispanic and Latino Individuals Receiving Hemodialysis: The Navigate-Kidney Randomized Clinical Trial

Lilia Cervantes, MD, MSc; Elizabeth Juarez-Colunga, PhD; Neil R. Powe, MD; et al.

Lifestyle Intervention for Sustained Remission of Metabolic Syndrome: A Randomized Clinical Trial

Lynda H. Powell, PhD; Jannette Berkley-Patton, PhD; Betty M. Drees, MD; et al.

Podcast: Lifestyle Intervention for Sustained Remission of Metabolic Syndrome

Podcast: From AHA: Coffee Consumption and Atrial Fibrillation, DASH-Patterned Groceries and Effects on Blood Pressure, Oral PCSK9 Inhibitor Enlicitide for Heterozygous Familial Hypercholesterolemia, and more

Durability of Respiratory Syncytial Virus Vaccine Effectiveness Among US Veterans

Kristina L. Bajema, MD; David P. Bui, PhD; Lei Yan, PhD; et al.

Editorial: The Importance of Real-World Evidence to Inform RSV Vaccine Guidance; Anna Hung, PharmD, PhD, MS; Lona Mody, MD, MSc

Women's Health

Sex Differences in Mortality and Receipt of Kidney Replacement Therapy Among Adults With Stage 5 Chronic Kidney Disease

Christian Chan, PhD; Simon Sawhney, PhD; Sofia B. Ahmed, MD, MMSc; et al.

Health Care Policy and Law

Changes in Health Care Utilization and Low-Value Service Use After Risk-Based Contract Adoption in Medicare Advantage

Aaron L. Schwartz, MD, PhD; Soohyun Kim, MS; Sumedha Chhatre, PhD; et al.

Editor's Note: Full Risk Yet Little Reward?—When Clinicians Take On Risk-Based Contracts in Medicare Advantage; Ishani Ganguli, MD, MPH

Health Equity

Physical Accessibility of Medicines in Countries Hosting Trials for FDA Approvals

Chris J. Lee, BS; Cary P. Gross, MD; Jennifer E. Miller, PHD

Editorial

AI and Clinical Care

Applying Clinical Licensure Principles to Artificial Intelligence

Eve Rittenberg, MD, MA; Roy Perlis, MD, MSc; Sharon Inouye, MD, MPH

The Importance of Real-World Evidence to Inform RSV Vaccine Guidance

Anna Hung, PharmD, PhD, MS; Lona Mody, MD, MSc

Invited Commentary

Women's Health

A Global Perspective to Improving Mammogram Completion Among Women Overdue for Breast Cancer Screening

Steven J. Atlas, MD, MPH

Defibrillators in Private Homes

Adam J. Boulton, MB, ChB; Hema Mistry, PhD; Gavin D. Perkins, DSc

Reducing Early Stroke Recurrence Risk—Beyond Antithrombotics

Ken Uchino, MD

Health Equity

Marketing Delays That Violate Global Ethical Standards—Participants but Not Patients

Joshua M. Sharfstein, MD; Lisa Ludeman, MSPH; Murray Lumpkin, MD, MSc

Health Care Policy and Law

When Academic Medical Centers Invest in Bringing Their Research to Market

Aleksandra Drmanovic, BA; So-Yeon Kang, PhD, MBA, MPH; Gerard Anderson, PhD

Editor's Note

AI and Clinical Care

Satisfaction in Writing

Deborah Grady, MD, MPH; Eve Rittenberg, MD, MA

Aging and Health

Online Digital Health Intervention—Safe and Scalable

Justin J. Choi, MD, MSc; Sharon K. Inouye, MD, MPH; Lona Mody, MD, MSc

Health Care Policy and Law

Full Risk Yet Little Reward?—When Clinicians Take On Risk-Based Contracts in Medicare Advantage

Ishani Ganguli, MD, MPH

Consequences of Grant Termination in Clinical Trials

Teva D. Brender, MD; Cary P. Gross, MD

Teachable Moment

Health Equity

Sexual Health in Cancer Care—A Gap in Understanding

Rylea K. Trudeau, BS; Olumide B. Gbolahan, MBBS, MSc; Emily Pinto Taylor, MD

Earn CME credit

Research Letter

Clinical Trials Affected by Research Grant Terminations at the National Institutes of Health

Vishal R. Patel, MD, MPH; Michael Liu, MD, MPhil; Anupam B. Jena, MD, PhD

Editor's Note: Consequences of Grant Termination in Clinical Trials; Teva D. Brender, MD; Cary P. Gross, MD

Health Equity

Opioid Prescribing Patterns in US Nursing Homes by Race and Ethnicity

Ulrike Muench, PhD; Matthew Jura, PhD; Krista L. Harrison, PhD; et al.

Health Care Policy and Law

Venture Capital Investments by Academic Medical Centers in Health Care Companies

Ravi Dhawan, MS; Denys Shay, MD; Anna Leland, BS; et al.

Health Care Policy and Law

US Food and Drug Administration Competitive Generic Therapy Approvals and Drug Competition

Kevin Kho, PhD; Rinku Patel, PharmD; Harinder Singh Chahal, PharmD, MSc.

Health Care Policy and Law

Characteristics of Speakers at US FDA Advisory Committee Meetings on Drug Approval

Leah Z. Rand, DPhil; Helen Mooney, MPH; Dongzhe Hong, PhD; et al.

Clinical Insights

Implementing Benzodiazepine Deprescribing in the Primary Care Clinic

Bryant Shuey, MD, MPH; Timothy S. Anderson, MD, MAS; Tae Woo Park, MD, MSc

Earn CME credit

Guide to Statistics and Methods

Active Comparator New User Cohort Studies and Matching

Til Stürmer, MD, MPH, PhD; Tiansheng Wang, PharmD, MS, PhD

Earn CME credit

Challenges in Clinical Electrocardiography

An Uncommon Cause of Bradycardia Treated With Catheter Ablation

Chan-Hee Lee, MD, PhD; Edward P. Gerstenfeld, MD

Earn CME credit

JAMA Internal Medicine Patient Page

What Do I Need to Know About the Pneumococcal Pneumonia Vaccine?

Jerard Z. Kneifati-Hayek, MD, MS; Michael A. Incze, MD, MSEd

Audio

Lifestyle Intervention for Sustained Remission of Metabolic Syndrome

From AHA: Coffee Consumption and Atrial Fibrillation, DASH-Patterned Groceries and Effects on Blood Pressure, Oral PCSK9 Inhibitor Enlicitide for Heterozygous Familial Hypercholesterolemia, and more

Comment & Response

Antibiotic Prophylaxis in Patients With Cirrhosis Presenting With Variceal Bleeding—Are We Treating the Past?

Kimberly K. I. M. Bot, MD; Koos de Wit, MD, PhD; Marten A. Lantinga, MD, PhD

Antibiotic Prophylaxis in Patients With Cirrhosis Presenting With Variceal Bleeding—Are We Treating the Past?—Reply

Connor Prosty, MD; Todd C. Lee, MD, MPH; Emily G. McDonald, MD, MSc

Frailty Assessment for Decision-Making in Older Patients With Acute Coronary Syndrome

Juan Sanchis, MD, PhD; Héctor Bueno, MD, PhD; Albert Ariza-Solé, MD, PhD

Aging and Health

Frailty Assessment for Decision-Making in Older Patients With Acute Coronary Syndrome—Reply

Rohin K. Reddy, MBBS, MSc; James P. Howard, MB, BChir, PhD; Yousif Ahmad, MD, PhD

Coprescribing GLP-1 Receptor Agonists and Lifestyle

Michelle S. Rockwell, PhD, RD; Elizabeth A. Polk, MD; Camille Mittendorf, BS

Coprescribing GLP-1 Receptor Agonists and Lifestyle—Reply

Farhad Mehrtash, MPH; Jody Dushay, MD, MMSc; JoAnn E. Manson, MD, DrPH

Correction

Error in Figure 2

Errors in Results

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